The ketone A was subjected to a reaction with LDA at -78 °C, followed by addition of isobutyraldehyde (Scheme). Provide the product B, including the stereochemistry at all relevant stereogenic centers. Show the mechanism of the reaction and draw a transition structure that clearly indicates how the stereoisomer is formed. A 1. LDA, -78°C 2. H B

The ketone A was subjected to a reaction with LDA at -78 °C, followed by addition of isobutyraldehyde (Scheme). Provide the product B, including the stereochemistry at all relevant stereogenic centers. Show the mechanism of the reaction and draw a transition structure that clearly indicates how the stereoisomer is formed. A 1. LDA, -78°C 2. H B

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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