Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Suppose you are testing the null hypothesis that the mode of inheritance for a particular disease in elegant cranes is sex-linked
recessive. You employ the following crosses, where R is the wild-type allele, r is the disease allele, and Y is Y-chromosome
allele (only in males):
Parental cross (Affected male with unaffected (carrier) female): rY x Rr.
F₁ cross (Unaffected male with affected female): RY x rr.
Suppose you perform these crosses at two different research locations. You obtain the following counts in the F2 generation:
Location 01
Male, Disease: 200
Male, Wild-type: 225
Female, Disease: 211
Female, Wild-type: 205,
Location 02
Male, Disease: 320
Male, Wild-type: 325
Female, Disease: 354
Female, Wild-type: 310
Do you reject or not reject the null hypothesis that the mode of inheritance is sex-linked recessive at each location? The
significance level is 0.01.
(Hint: when applying the ChiSq goodness of fit test, if the expected value for a row is 0, remove that row and reduce the
degrees of freedom by 1).
0 00
Do not reject the null hypothesis regarding the modes of inheritance at the two different locations since the Fisher's
method p-value is greater than the significance level.
The modes of inheritance at each research location appear to be autosomal recessive. From this information only, we
reject Fisher's null hypothesis.
The degrees of freedom for Fisher's method in this question are 8.
The F2 data are not possible, given the specified F₁ cross. Therefore, the information in this question is irrelevant, and
no answer can be provided.
Reject the null hypothesis regarding the modes of inheritance at the two different locations since the Fisher's meth
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Transcribed Image Text:Suppose you are testing the null hypothesis that the mode of inheritance for a particular disease in elegant cranes is sex-linked recessive. You employ the following crosses, where R is the wild-type allele, r is the disease allele, and Y is Y-chromosome allele (only in males): Parental cross (Affected male with unaffected (carrier) female): rY x Rr. F₁ cross (Unaffected male with affected female): RY x rr. Suppose you perform these crosses at two different research locations. You obtain the following counts in the F2 generation: Location 01 Male, Disease: 200 Male, Wild-type: 225 Female, Disease: 211 Female, Wild-type: 205, Location 02 Male, Disease: 320 Male, Wild-type: 325 Female, Disease: 354 Female, Wild-type: 310 Do you reject or not reject the null hypothesis that the mode of inheritance is sex-linked recessive at each location? The significance level is 0.01. (Hint: when applying the ChiSq goodness of fit test, if the expected value for a row is 0, remove that row and reduce the degrees of freedom by 1). 0 00 Do not reject the null hypothesis regarding the modes of inheritance at the two different locations since the Fisher's method p-value is greater than the significance level. The modes of inheritance at each research location appear to be autosomal recessive. From this information only, we reject Fisher's null hypothesis. The degrees of freedom for Fisher's method in this question are 8. The F2 data are not possible, given the specified F₁ cross. Therefore, the information in this question is irrelevant, and no answer can be provided. Reject the null hypothesis regarding the modes of inheritance at the two different locations since the Fisher's meth
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