Answered: Suppose we want to design a new…

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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Suppose we want to design a new placebo-controlled trial to evaluate an experimental medication to increase lung capacity. The primary outcome is peak expiratory flow rate, a continuous variable measured in liters per minute. The primary outcome will be measured after 6 months of treatment. The mean peak expiratory flow rate in adults is 300l/min with a standard deviation of 50 l/min. How many subjects should be enrolled to ensure 80% power to detect a difference of 15 l/min with a two-sided test and a=0/5? The investigators expect to lose 10% of the participants over the course of follow-up.

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