Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Macmillan Learning Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCI) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI dipole-dipole hydrogen bond polarizability, size; molecular weight ionic interaction Incorrect Species able to form that NCI any species with permanent dipoles (C-O, etc.) H bonded to N, O, or F and F dielectric size; type of charge Answer Bank Parameters affecting the NCI ions; charged species strength and orientation of dipole orientation dispersion Resources C O
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Transcribed Image Text:Macmillan Learning Suppose a drug molecule binds to a protein target. Complete the table which describes possible noncovalent interactions (NCI) in the binding site. Assume the drug has a variety of types of polar and nonpolar regions. Type of NCI dipole-dipole hydrogen bond polarizability, size; molecular weight ionic interaction Incorrect Species able to form that NCI any species with permanent dipoles (C-O, etc.) H bonded to N, O, or F and F dielectric size; type of charge Answer Bank Parameters affecting the NCI ions; charged species strength and orientation of dipole orientation dispersion Resources C O
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