Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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### Synthesis of Phenylacetic Acid from Diethyl Malonate

**Objective:**  
Starting with diethyl malonate, demonstrate how to synthesize the following compound using reagents of your choice:

**Target Compound:**  
- Phenylacetic acid (PhCH2COOH)

**Starting Material:**  
- Diethyl malonate (CH2(COOC2H5)2)

**Transformation Description:**  
The target compound can be formed through a series of reactions using a combination of the reagents listed below:

**Reagents Listed:**

A. \[ \text{PhCH}_2\text{Br} \]  

B. \[ \text{Ph}_2\text{CHBr} \]  

C. \[ \text{NaOEt} \]  

D. \[ \text{H}_3\text{O}^+, \text{heat} \]  

E. \[ \text{CH}_3\text{I} \]  

F. \[ \text{PhBr} \]  

**Instructions:**  
To execute the synthesis in the correct order, input the corresponding letters of the required reagents as a string (e.g., "EBF"), without any spaces or punctuation. If alternate correct solutions exist, only one solution needs to be provided.

**Note:**  
Understanding the order and type of reactions involved, such as alkylation and hydrolysis, is crucial in achieving the successful synthesis of the target compound.
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Transcribed Image Text:### Synthesis of Phenylacetic Acid from Diethyl Malonate **Objective:** Starting with diethyl malonate, demonstrate how to synthesize the following compound using reagents of your choice: **Target Compound:** - Phenylacetic acid (PhCH2COOH) **Starting Material:** - Diethyl malonate (CH2(COOC2H5)2) **Transformation Description:** The target compound can be formed through a series of reactions using a combination of the reagents listed below: **Reagents Listed:** A. \[ \text{PhCH}_2\text{Br} \] B. \[ \text{Ph}_2\text{CHBr} \] C. \[ \text{NaOEt} \] D. \[ \text{H}_3\text{O}^+, \text{heat} \] E. \[ \text{CH}_3\text{I} \] F. \[ \text{PhBr} \] **Instructions:** To execute the synthesis in the correct order, input the corresponding letters of the required reagents as a string (e.g., "EBF"), without any spaces or punctuation. If alternate correct solutions exist, only one solution needs to be provided. **Note:** Understanding the order and type of reactions involved, such as alkylation and hydrolysis, is crucial in achieving the successful synthesis of the target compound.
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