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Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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
Transcribed Image Text:Some microorganisms have evolved cellular machinery that carries out chemical transformations
in a manner analogous to that of the pyruvate dehydrogenase complex (PDC). One example of these
remarkable transformations is shown below.
معلم
H3C
1. TPP
2. lipoamide
CH3
+
3. Coenzyme A H3C
H
H3C
SCOA
он
Provide a complete curved-arrow mechanism for all three steps of this multistep enzymatic transformation.
You may abbreviate the structure of Coenzyme A as "COA-SH" in your mechanism. You do not have to show
a mechanism for the regeneration of the lipoamide cofactor.
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