Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin: hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia Explain how inheriting the sickle cell mutation affects the cellular processes of transcription and translation.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Question
100%

26

Sickle Cell Anemia
Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle
cell mutation affects the structure of hemoglobin; hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive
allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia.
Normal genotype
DNA GAC TGA GGA CTC
mRNA CU|G| ACU CCUGAG GAG
Amino acid
sequence
Glutamic
acid
Leucine Threonine Proline
mRNA|C|U|G
Amino acid
sequence
Sickle cell anemia genotype
DNA GAC TGA GGA CAC CTC
Glutamic
acid
Normal
CTC
Leucine Threonine Proline
ACU CCU GUG GAG
Glutamic
acid
Valine
Mutant
Normal red blood cells
35
nocul
Sickled red blood cells
Explain how inheriting the sickle cell mutation affects the cellular processes of transcription and translation.
Transcribed Image Text:Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin; hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia. Normal genotype DNA GAC TGA GGA CTC mRNA CU|G| ACU CCUGAG GAG Amino acid sequence Glutamic acid Leucine Threonine Proline mRNA|C|U|G Amino acid sequence Sickle cell anemia genotype DNA GAC TGA GGA CAC CTC Glutamic acid Normal CTC Leucine Threonine Proline ACU CCU GUG GAG Glutamic acid Valine Mutant Normal red blood cells 35 nocul Sickled red blood cells Explain how inheriting the sickle cell mutation affects the cellular processes of transcription and translation.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Hematology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education