SCIENTIFIC INQUIRY • DRAW IT Assume you are mappinggenes A, B, C, and D in Drosophila. You know that these genesare linked on the same chromosome, and you determine therecombination frequencies between each pair of genes to be asfollows: A–B, 8%; A–C, 28%; A–D, 25%; B–C, 20%; B–D, 33%.(a) Describe how you determined the recombinationfrequency for each pair of genes.(b) Draw a chromosome map based on your data
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SCIENTIFIC INQUIRY • DRAW IT Assume you are mapping
genes A, B, C, and D in Drosophila. You know that these genes
are linked on the same chromosome, and you determine the
recombination frequencies between each pair of genes to be as
follows: A–B, 8%; A–C, 28%; A–D, 25%; B–C, 20%; B–D, 33%.
(a) Describe how you determined the recombination
frequency for each pair of genes.
(b) Draw a chromosome map based on your data
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- . In the plant Arabidopsis thaliana, a geneticist is interested in the development of trichomes (small projections). A large screen turns up two mutant plants (A and B) that have no trichomes, and these mutants seem to be potentially useful in studying trichome development. (If they were determined by single-gene mutations, then finding the normal and abnormal functions of these genes would be instructive.) Each plant is crossed with wild type; in both cases, the next generation (F1) had normal trichomes. When F1 plants were selfed, the resulting F2’s were as follows: F2 from mutant A: 602 normal; 198 no trichomes F2 from mutant B: 267 normal; 93 no trichomesa. What do these results show? Include proposed genotypes of all plants in your answer. b. Under your explanation to part a, is it possible to confidently predict the F1 from crossing the original mutant A with the original mutant B?VISUALIZE Sketch a series of diagrams showing each of the following, making sure to end each series with haploid cells: (a)How a pair of alleles for a single locus segregate in meiosis (b)How the alleles of two unlinked loci assort independently in meiosis (c)How the alleles of two linked loci undergo genetic recombination. Genomes A, B, and C all have basic chromosomenumbers (x) of nine. These genomes were derivedoriginally from plant species that had diverged from each other sufficiently far back in the evolutionarypast that the chromosomes from one genome can nolonger pair with the chromosomes from any other genome. For plants with the following kinds of euploidchromosome complements, (i) state the number ofchromosomes in the organism; (ii) provide terms thatdescribe the individual’s genetic makeup as accurately as possible; (iii) state whether or not it is likelythat this plant will be fertile, and if so, give the number of chromosomes (n) in the gametes.a. AABBCb. BBBBc. CCCd. BBCCe. ABCf. AABBCC
- For practice construct a Genetic map with three genes in Arabidopsis plants. A short plant (hy) is recessive to tall plant (HY), a red flower (r) is recessive to white flower (R); and long pollen (po) is recessive to oval shaped pollen (PO). You can come up with arbitrary number of progenies for each class of offspring (follow the numbers like in Fig. 7.14) ( please help, I dont understand what/how to do this)F1 Generation Cross F2 Generation (at least 500 flies) Fl red-eyed females x white-eyed males 50% of females are red-eyed and 50% are white- eyed 50% of males are red-eyed and 50% are white-eyed 21. The best explanation for the red-eyed F1 females is (A) mutation (B) culture contamination (C) dominance (D) multiple loci (E) sex-influenced traits 22. There are white-eyed females in the F2 generation because (A) white is a dominant allele (B) the white allele is autosomal (C) a mutation has occurred (D) these F2 females have two white alleles (E) the white allele is located on the Y chromosome 23. Which of the following best describes the mode of inheritance of eye color in the white culture? (A) Autosomal (B) Dominant (C) Located on the Y chromosome (D) Sex-linked (E) Lethal 24. Assume that genes A and B are not linked. If the probability of allele A in a gamete is 1/2 and the probability of allele B in a gamete is 1/2, then the probability that both A and B are in the same gamete is…Construct a genetic map using the following data: A line of drosophila has been constructed with three recessive mutations: sc = loss of thorax bristles ("scute") ec = roughened eye surface ("echinus") vg = vestigial wings The dominant, wild-type version of each allele could be written as vg + or ec+, but we will write them just as "+" for simplicity. P generation: We cross homozygous recessive flies (sc ec vg / sc ec vg) with homozygous dominant (wild-type) flies (+ + + / + + +). F1 generation: All of the flies produced by the parental cross have the dominant (wild-type) phenotype. Genetically, these flies are: (sc ec vg / + + + ). F2 generation: We produce an F2 generation by mating the F1 flies with homozygous recessive flies (sc ec vg / sc ec vg) This cross produces an F2 generation with 8 different phenotypes: All wild type features – 430 echinus – 5 echinus, vestigial – 29 scute – 25 scute, echinus – 44 scute, echinus, and vestigial – 417 scute,…
- In Drosophila sex determination (Check all that apply.) A) XY individuals transcribe the Sxl gene early but not late. B XX individuals carry the Sxl gene, XY individuals do not. XX individuals transcribe the Sxl gene, XY individuals do not. XX individuals express the Sxl protein, XY individuals do not. E) The Sxl transcript (Pre-MRNA) is spliced differently in XX compared to XY individuals.Examine the set of three-point mapping data from Drosophilainvolving two dominant mutations [Stubble (Sb) and Lyra (Ly)]and one recessive mutation [bright (br)]. Identify the categoriesof data below (1–8) that are essential in establishing:(a) the arrangement of alleles in the crossover parent;(b) the sequence of the three genes along the chromosome;and (c) the interlocus distance between the genes.Phenotype Number(1) Ly Sb br 404(2) + + + 422(3) Ly + + 18(4) + Sb br 16(5) Ly + br 75(6) + Sb + 59(7) Ly Sb + 4(8) + + br 2 Total = 1000Deletions in bacterial chromosomes give the following data: Region of deletion Al Gene A activity +++ A2 АЗ A4 AS +++ (i) Where is the gene located? Explain your answer. Name the scientific term that describes the appearance of a recessive phenotype due to deletion of dominant gene. (ii) (iii) The phenotypic consequences of deletion depend on two factors. What are they? Give one example of human genetic disorder caused by chromosomal deletion by indicating the region of deletion in chromosome. (iv)
- Drosophila can have 1, 2, or 3 stripes on their body. From previous experiments, you suspect that there are 2 genes (Gene C and Gene D) that control the number of stripes. A recent published paper described a similar stripe pattern in bees. Furthermore, in bees, Gene C is recessively epistatic to Gene D, are on different chromosomes, and the order of function is the following: C D 3 stripes → 2 stripes 1 stripe You therefore set out to test the hypothesis that Gene Cis also recessively epistatic to Gene D in Drosophila. To do so, you begin by crossing pure breeding 1-striped drosophila with pure breeding 3-stripped drosophila. To statically test your hypothesis, you proceed to perform a chi-square analysis on data obtained from the F1 X F1 cross. Using your hypothesis as your basis to analyze the results, fill the table below. Note: You do not have to calculate the chi-square or make a conclusion. Just fill the table. Observed Еxpected Нуpothesized Phenotypic ratio Phenotypes F2…In Drosophila (fruit flies), jammed wings (J), daughterless (da), curly wings (Cy), star eyes (S), and a black body (b) are determined by genes located on the same chromosome. Gene Combination Recombination Frequency J and Cy 34.9 J and da 1.7 S and Cy 4.8 Cy and b 42.4 S and da 38 b and S 47.2 What is the map unit distance between b and da?Answer map unitsRecord your answer as a value rounded to one decimal place.In Drosophila, an X-linked recessive mutation, scalloped (sd),causes irregular wing margins. Diagram the F1 and F2 resultsif (a) a scalloped female is crossed with a normal male; (b) ascalloped male is crossed with a normal female. Compare theseresults to those that would be obtained if the scalloped gene wereautosomal.