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- Briefly present your explanation why lipid-lowering drugs can prevent atherosclerosis progression.Present the comparison of clinical benefit of statins and fibrates in the management of patients with atherosclerosis.1. You are a lead engineer in a cGMP facility that develops and delivers tissue engineering constructs for tissue regeneration. You have been asked to develop an injectable tissue engineering solution for regenerating heart tissue following myocardial infarction. A) Describe an injectable tissue engineering solution to regenerate the damaged heart tissue by considering the following and give a brief explanation for your choices: i) Cell type and source
- 1. You are a lead engineer in a cGMP facility that develops and delivers tissue engineering constructs for tissue regeneration. You have been asked to develop an injectable tissue engineering solution for regenerating heart tissue following myocardial infarction. A) Describe an injectable tissue engineering solution to regenerate the damaged heart tissue by considering the following and give a brief explanation for your choices: i) Injectable scaffold material, include class of scaffold (i.e synthetic/natural? hydrogel?Hyperglycemia associated with diabetes promotes a prothrombotic state by affecting a number of different steps in the clotting pathway. Which of the following would result in more rather than less clotting? Check all that apply. The correct answers reflect the effect of hyperglycemia on the clotting pathway! less conversion of plasminogen to plasmin 7 000000000 abnormally low number of platelets platelets more sensitive to thromboxane A2 elevated conversion of plasminogen to plasmin platelets less sensitive to thromboxane A2 low sensitivity to NO and PGI2 increased prothrombin in the blood increased amount of fibrinogen in the blood less prothrombin in the blood abnormally high number of platelets less fibrinogen in the blood high sensitivity to NO and PGI2From the experimental activity for PhysioEX Which of the following forms the (Y) axis of this graph Which of the following forms the (X) axis of this graph (A) Y - vessel length / X - flow rate (B) Y - flow rate / X - vessel length (C) Y - flow rate / X - peripheral resistance (D) Y - peripheral resistance / X - flow rate
- 1. You are a lead engineer in a cGMP facility that develops and delivers tissue engineering constructs for tissue regeneration. You have been asked to develop an injectable tissue engineering solution for regenerating heart tissue following myocardial infarction. Describe an injectable tissue engineering solution to regenerate the damaged heart tissue by considering the following and give a brief explanation for your choices: 1) Bioreactor for examining tissue growth and integrityWhat are the current challenges involved in the treatment of atherosclerosis at activated endothelium with conventional therapeutics, e.g., aspirin or Acebutolol?Of the available types of surgery, why would TURBT be a choice for many patients despite the high risk of relapse post-surgery? Give at least two reasons why patients might select this option.
- What is angiogenesis? Explain how anti-angiogenic agents can be used in cancer therapeuticsIndividuals undergoing anti-angiogenesis therapy with VEGF inhibitors often show initial reduction in tumor volume, but quickly develop resistance to the therapy. Resistant patients have elevated levels of Fibroblast Growth Factors (FGF) and Platelet Derived Growth Factors (PDGF) compared to patients that do not develop resistance. Briefly explain the two likely mechanisms by which these patients developed resistance.can atherosclerosis prevent by antioxidants? Explain your answer
