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[Review Topics] [References] Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed the following reaction. + H₂N • You do not have to consider stereochemistry. . Include all valence lone pairs in your answer. OH Do not include counter-ions, e.g., Nat, I, in your answer. - In cases where there is more than one answer, just draw one.

[Review Topics] [References] Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed the following reaction. + H₂N • You do not have to consider stereochemistry. . Include all valence lone pairs in your answer. OH Do not include counter-ions, e.g., Nat, I, in your answer. - In cases where there is more than one answer, just draw one.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Draw the tetrahedral intermediate as it is first formed in the following reaction. I keep getting it wrong. 

### Educational Content on Acyl Transfer Reactions **Acyl transfer (nucleophilic substitution at carbonyl) reactions** proceed in two stages via a "tetrahedral intermediate." The task is to draw the tetrahedral intermediate **as it is first formed** in the following reaction: **Reaction Components:** - **Reactants:** - An acyl chloride with a benzene ring (phenyl group) attached to a carbonyl group (C=O) and a chlorine atom. - A compound containing an amine group (NH₂) and an alcohol group (OH). - **Reaction Arrow:** Indicates the progression from reactants to products through the formation of an intermediate. **Instructions:** - **Stereochemistry:** - You do not have to consider stereochemistry for this task. - **Valence Lone Pairs:** - Include all valence lone pairs in your drawing of the tetrahedral intermediate. - **Counter-Ions:** - Do not include counter-ions such as Na⁺ or I⁻ in your answer. - **Multiple Possible Answers:** - If there is more than one possible answer for the intermediate, draw only one. **Diagrams and Tools:** - Below the instruction text, various tool icons are visible which may be used for drawing chemical structures, indicating bonds, and incorporating lone pairs into diagrams. ### Note: It is important to understand the mechanism of acyl transfer reactions and be able to illustrate intermediates, as they play a crucial role in organic synthesis. Accurate depiction of lone pairs and structural changes is essential for mastering reaction mechanisms.
Transcribed Image Text:### Educational Content on Acyl Transfer Reactions **Acyl transfer (nucleophilic substitution at carbonyl) reactions** proceed in two stages via a "tetrahedral intermediate." The task is to draw the tetrahedral intermediate **as it is first formed** in the following reaction: **Reaction Components:** - **Reactants:** - An acyl chloride with a benzene ring (phenyl group) attached to a carbonyl group (C=O) and a chlorine atom. - A compound containing an amine group (NH₂) and an alcohol group (OH). - **Reaction Arrow:** Indicates the progression from reactants to products through the formation of an intermediate. **Instructions:** - **Stereochemistry:** - You do not have to consider stereochemistry for this task. - **Valence Lone Pairs:** - Include all valence lone pairs in your drawing of the tetrahedral intermediate. - **Counter-Ions:** - Do not include counter-ions such as Na⁺ or I⁻ in your answer. - **Multiple Possible Answers:** - If there is more than one possible answer for the intermediate, draw only one. **Diagrams and Tools:** - Below the instruction text, various tool icons are visible which may be used for drawing chemical structures, indicating bonds, and incorporating lone pairs into diagrams. ### Note: It is important to understand the mechanism of acyl transfer reactions and be able to illustrate intermediates, as they play a crucial role in organic synthesis. Accurate depiction of lone pairs and structural changes is essential for mastering reaction mechanisms.
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