Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Retinoblastoma can be seen as a familial cancer, inherited in an autosomal recessive manner (RB-/RB-), individuals heterozygous for the RB+ and RB- alleles can develop tumor as a result of…
- A mitotic crossover that leads to homozygosity for RB+ in some cells and RB- in other cells
- A meiotic mutation in the RB+ allele that leads to homozygosity for RB+
- A somatic mutation in the RB- allele that leads to homozygosity for RB+
- The fact that RB- is dominant to RB+
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