Retinoblastoma can be seen as a familial cancer, inherited in an autosomal recessive manner (RB-/RB-), individuals heterozygous for the RB+ and RB- alleles can develop tumor as a result of… A mitotic crossover that leads to homozygosity for RB

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter12: Genes And Cancer
Section: Chapter Questions
Problem 12QP
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Retinoblastoma can be seen as a familial cancer, inherited in an autosomal recessive manner (RB-/RB-), individuals heterozygous for the RB+ and RB- alleles can develop tumor as a result of…

  1. A mitotic crossover that leads to homozygosity for RB+ in some cells and RB- in other cells
  2. A meiotic mutation in the RB+ allele that leads to homozygosity for RB+
  3. A somatic mutation in the RB- allele that leads to homozygosity for RB+
  4. The fact that RB- is dominant to RB+
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