Regarding the mechanisms of chronic disease, which of the following statements is NOT true? O Intermediate risk factors like hypertension and early-onset diabetes are irreversible, making lifestyle changes irrelevant O Many vitamins function as enzymatic cofactors in the human body O In the context of oxidative stress and inflammation, the blood tends to become hypercoagulable (more prone to clotting) O Alcohol consumption greatly increases oxidative stress in liver cells
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- Regarding chronic inflammation, which of the following statements is NOT correct? Omega-6 fatty acids tend to be pro-inflammatory while omega-3 fatty acids participate in anti-inflammatory pathways x Glycemic index is a measure of the impact a carbohydrate-containing food has on blood glucose Visceral fat and high blood pressure are both risk factors for chronic inflammation Chronic inflammation is driven by pro-inflammatory cytokines like melatonin and superoxide dismutaseRegular physical activity has demonstrated evidence to reduce rates of O Peripheral vascular disease OCoronary artery disease O Stomach cancer O OsteoarthritisExplain why untreated Addison’s disease could belife threatening.
- Describe basic alterations in normal hormonal regulation and feedback that cause disease and also Describe the role of social and environmental determinants of health in pathogenesis of diseases of hormonal and metabolic regulationDiscuss the different types of lipoproteins and their role in cardiovascular diseases and in hyperlipidemiaWould a patient with familial hypercholesterolemia (FH) benefit fromdietary changes?
- Consider the person Harrison Johnson, aged 21, was diagnosed with Type 1 diabetes mellitus when he was 12 years old after a viral illness. He and his family learned to manage his diabetes although his teenage years were difficult with episodes of low and high blood glucose. He is now a 3rd year nursing student and enjoys the course very much. However, at times he has found the study and PEP stressful, and this has made managing his blood glucose difficult at times. He is very active and enjoys running and football, and nights out with his friends. Harrison acquired both a continuous glucose monitor and an insulin pump 3 months ago. He is still learning how to use them effectively. Last week Harrison developed a heavy cold with a significant green mucus discharge. He has been feeling very unwell, experiencing episodes of rigors and fever. He has a productive cough. He has presented to the clinic feeling even worse, very tired, thirsty, and urinating more frequently. Collect cues Vital…Consider the person Harrison Johnson, aged 21, was diagnosed with Type 1 diabetes mellitus when he was 12 years old after a viral illness. He and his family learned to manage his diabetes although his teenage years were difficult with episodes of low and high blood glucose. He is now a 3rd year nursing student and enjoys the course very much. However, at times he has found the study and PEP stressful, and this has made managing his blood glucose difficult at times. He is very active and enjoys running and football, and nights out with his friends. Harrison acquired both a continuous glucose monitor and an insulin pump 3 months ago. He is still learning how to use them effectively. Last week Harrison developed a heavy cold with a significant green mucus discharge. He has been feeling very unwell, experiencing episodes of rigors and fever. He has a productive cough. He has presented to the clinic feeling even worse, very tired, thirsty, and urinating more frequently. Collect cues Vital…Diets aimed at reducing coronary heart disease should be: low in trans-fatty acids and high in saturated fatty acids. O low in trans-fatty acids and low in saturated fatty acids. low in trans-fatty acids and low in unsaturated fatty acids. O high in trans-fatty acids and high in saturated fatty acids.
- Which of the following pairs of lipid-soluble vitamin:function is/are WRONG? Vit K:synthesis of Ca-binding proteins for blood clotting U Vit C:anti-oxidant Vit E:remove free radicals Vit D:regulation of Ca and P metabolism Vit A:site of photochemical reaction in visionop of Form Normal Levels of Substances in the Arterial Blood: pH 7.40 + 0.05 pCO2 (partial pressure of carbon dioxide) 40 mm Hg pO2 (partial pressure of oxygen) 90 - 100 mm Hg Hemoglobin - O2 saturation 94 - 100 % [HCO3-] 24 meq / liter Vignette #1: A 21-year-old noncompliant female with a history of type I (insulin-dependent) diabetes mellitus was found in a coma. Her blood glucose was high, as well as her urine glucose, urine ketones, and serum ketones. Her serum bicarbonate was < 12 mEq/L. Her respiration was exaggerated, and her breath had an acetone odor. Her blood pressure was 90/60 and his pulse weak and rapid (120). 1. Define noncompliant. 2. Is this person experiencing ketoacidosis or insulin shock? Explain your answer. 3. Why is the serum bicarbonate low? 4. What is the acid-base status of this individual? 5. What are the causes of the dyspnea, hypotension, and tachycardia? 6. What type of treatment does this person need?…5. There is an expression: diabetes mellitus is «hunger among abundance. What metabolic changes in diabetes confirm the validity of this statement? For answer: 9.8. Metabolic Changes in Diabetes Mellitus 535 a) list the main causes of metabolic changes in IDDM; b) enumerate the tissues with the main energy sources metabolism procceding according to this type of starvation; c) name the metabolic pathways that are activated and inhibited in these tissues, and explain why; d) list the symptoms of diabetes mellitus, that reflect such metabolic changes; c) draw a diagram of one of the mctabolic pathways that is activated in the liver under these conditions and explain the consequences of such activation.