Reaction of a primary or secondary amine with diethyl carbonate under controlled con- ditions gives a carbamic ester. EtO OEt + H,N EtO `N. H + ELOH Diethyl carbonate Butylamine Ethyl N-butylcarbamate Propose a mechanism for this reaction.

How would you prepare 3-phenyl-1-propanamine (C&H-CH₂CH₂CH₂NH₂) from C&H,CH₂CH₂CHO C HẠCH,CH,CHO Select the correct reagent for A. Ⓡ (CH,ANH, ơi (CH₂)NO > C HẠCH,CH,CH;NH, NaBH, CN CHÍNH, Ố NH₁ ?

H₂C 0 NH₂ B₂, NaOH 98 H₂C OH When an a-hydroxy amide is treated with try in aqueous NaOH under Hofmann rearrangement conditions, loss of CO, occurs and a chain-shortened aldehyde is formed. The mechanhum involves the following steps: Base abstracts an acidic amide proton, yielding amide anion The amide anion reacts with bromine in an e-substitution reaction to give N-bromoamide 2. Abstraction of the remaining amide proton by base gives a resonance-stabilized bromoamide anion Rearangement occurs to yield isocyanate Water adds to the isocyanate to yield carbamic acid Elimination of CD, yields carbinolamine Following proton transfer, expubion of ammonia yields the final product aldehyde Write out the mechanism on a separate sheet of paper, and then draw the structures of carbamic acid 5 and isocyanate 4. H 400, ANH, You do not have to consider stereochemistry. You do not have to explicitly draw Hatoms De not include lone pairs in your answer. They will not be considered in the grading…

Select the appropriate reagent and TWO possible substrates for the following reductive amination.

NOC XT Ph CH₂ Both primary and secondary amines add to a ß-unsaturated aldehydes and ketones to yield ß-amino aldehydes and ketones rather than the alternative imines. Under typical reaction conditions, both direct and conjugate modes of addition occur rapidly. But because the reactions are reversible, they generally proceed with thermodynamic control rather than kinetic control so the more stable conjugate addition product is often obtained to the complete exclusion of the less stable direct addition product. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions H H CH3NH₂ CH3 H-A :A Ph NHCH3 вон CH3 :A H-A 8b

Please answer with explanations and make it easy to read

Show how to synthesize the following amines from the indicated starting materials byreductive amination. (±)-amphetamine 1-phenylpropan-2-one

The compound 4-isobutylacetophenone is needed for the synthesis of ibupro- fen. Propose a synthesis of 4-isobutylacetophenone from benzene and any other necessary reagents. several steps COOH 4-Isobutylacetophenone Ibuprofen (racemic)

1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine involves the following Grignard reaction. Give the major product and propose a reasonable mechanism for the following reaction: H CI 1) 2) HCI, H₂O MgBr diethyl ether

What synthesis proposal can I use?