Organic Chemistry
9th Edition
ISBN: 9781305080485
Author: John E. McMurry
Publisher: Cengage Learning
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- Rank the reactivity of the compounds below toward nucleophilic acyl substitution by writing the compounds' letters in the proper blanks in the box below. `NH CI Br CH3 CH3 A В C E rank compounds for acyl substitution reactivity most least reactive reactivearrow_forwardElectrostatic potential maps of anisole and thioanisole are shown. Which do you think is the stronger acid, p-methoxybenzoic acid or p-(methylthio)benzoic acid? Explain.arrow_forwardArrange the structure on the image with regard to the reactivity towards nucleophilic acyl substitution 1 being the least and 3 being the mostarrow_forward
- Rank the following compounds from MOST react Mucieophilic acyl substitution. Enter the number 1 in the and number 3 in the box under the least reactive compou om bajada! 517 om oonuod O ofque ex Explain why 1 is more reactive compared to 2arrow_forwardProvide a plausible arrow pushing mechanism for the reaction below. 1 eq. H20 MEOH Но. OMe cat. H-A OHarrow_forwardWhich of the following structures and IUPAC names are incorrectly matched? * oe (A) Methyleyclohexanoate (В) `NH2 Br 4-Bromo-3-chlorohexanamide 2-Ethoxypentane (D) HOOC HOOC 3,5-Nonanedioic acid В A Darrow_forward
- Provide an arrow pushing mechanism for the following reactionarrow_forwardCoumarin, a naturally occurring compound isolated from lavender, sweet clover, and tonka bean, is made in the laboratory from o hydroxybenzaldehyde by the reaction depicted below. Draw a stepwise mechanism for this reaction. Coumarin derivatives are useful synthetic anticoagulants.arrow_forwardIf anhydrides react like acid chlorides with the nucleophiles, draw the products formed when each of the following nucleophiles reacts with benzoic anhydride [(C6H5CO)2O]: (a) CH3MgBr (2 equiv), then H2O; (b) LiAlH4, then H2O; (c) LiAlH[OC(CH3)3]3, then H2O.arrow_forward
- 4) Rank the following compounds in order of increasing reactivity (least to most reactive) with respect to acyl substitution. I. methyl benzoate II. benzoylchloride III. benzamide III < | < ||arrow_forwardplease provide major product!arrow_forwardWould you please help me with the explanation and all detailarrow_forward
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