Please explain how this reaction happens R- NH2NHHO.NHDCC,THFNHRT, N2 (atm.)Вос*NH2Вос`NH26(b-e)R= -CH,CH(CH,),.(2b)-CH,Ph,(2c)-CH,CH,-S-CH3,(2d)Acetone,72°C,-Ph,(3e)8hr.RR.H;PO,(85%)NH2THF,RT,24hr.NH8(b-e)Вос7(b-e)NCSAcetone,refluxRNH.N.CF39(b-e)

The reaction involves deprotection of amine group and results in formation of desired heterocyclic…

R - NH2 NH. HO NH DCC,THF NH RT, N2 (atm.) Вос `NH2 Вос `NH2 6(b-e) R= -CH,CH(CH,),.(2b) -CH,Ph,(2e) -CH,CH,-S-CH3(2d) -Ph,(3e) Acetone, 72°C, 8hr. R H,PO(85%) NH2 THF RT,24hr. NH 8(b-e) Вос 7(b-e) NCS Acetone, reflux H CF3 9(b-e)

R - NH2 NH. HO NH DCC,THF NH RT, N2 (atm.) Вос `NH2 Вос `NH2 6(b-e) R= -CH,CH(CH,),.(2b) -CH,Ph,(2e) -CH,CH,-S-CH3(2d) -Ph,(3e) Acetone, 72°C, 8hr. R H,PO(85%) NH2 THF RT,24hr. NH 8(b-e) Вос 7(b-e) NCS Acetone, reflux H CF3 9(b-e)

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Related questions

Q: Explain why increasing temperature increases the rate of reaction.

A: Since by increasing the temperature of the reaction, we are providing more energy to the molecules…

Q: Time (min) [X] (M) 0.467 1 0.267 0.187 0.144 4 0.117 0.099 0.085 7 0.075

A: Since we know that, for different order of reactions, the relationship between the concentration of…

Q: Reactant?

Q: n studying a reaction that goes to completion (this is not a reversible reaction) what happens to…

A: For a reaction aA + bB →cC + dD Rate is given as Rate = K[A]a [B]b

Q: How does general acid catalysis lower activation energy? How does general base catalysis increase…

A: General acid catalysis is a type of enzyme-catalyzed reaction in which a proton is transferred from…

Q: Consider the following two energy diagrams: Energy T Reactants According to the information…

Q: When the concentration of reactant increases, what effect will this have on the rate of the reaction…

A: All reactions possess a particular rate. That rate always carries direct relation with reactant's…

Q: In general, what is the relationship between reaction rateand reactant concentration?

A: The rate of reaction depends on 3 factors: concentration, temperature, and catalysts. Reaction is…

Q: Why does the rate of the reaction slow down with time? The rate constant slows with time because…

A: We need to explain why the rate of reaction becomes less with time.

Q: 1. Reaction rates increases with temperature. Describe at least two reasons why this happens.

A: Please find the attached images for the answer

Q: Which of the following is NOT TRUE: A) An increase in the activation energy of a reaction will…

Q: According to the model of chemical reactions developed in class, explain why adding a catalyst can…

A: Activation energy is the minimum amount of energy required for a chemical reaction to proceed in the…

Q: Study the following reaction energy diagram: energy reactants Then answer the following questions…

Q: what factors may affect the rate of the reaction

A: Given that : We have to determine the factors that affect the rate of the reaction.

Q: Indicate which factor would have the greatest impact on the rate of reaction. Choose from…

A: The rate of reaction is the measure of how fast or slow a chemical reaction occurs. It refers to the…

Q: Whea the conceatratioas of reactaat molecules are iacreased, the ate of reaction increases. The best…

Q: true or false catalyst work by decreasing the activation energy barrier between reactants and the…

A: Catalyst increases the rate of reaction by decreasing the activation energy of the reaction.…

Q: Describe how various factors influence the rate of reaction.

A: The rate of reaction is influenced by various factors.Let's discuss the various factors in the next…

Q: Which factor lower the rate of a chemical reaction? I. Increasing the temperature II. Removing the…

A: The temperature dependence of rate of a reaction is explained by Arrhenius equation. Arrhenius…

Q: Explain the Energy Diagram for a Two-Step Reaction Mechanism ?

A: Two step reaction mechanism: SN1 reaction is an example of two step reaction mechanism. Step1:…

Q: What are the properties of a solution to monitor the rate of reaction? What technique should be used…

A: The rate of a chemical reaction is defined as the measurement of the speed of the reactants to form…

Q: Summarize Temperature and Reaction Rate?

A: Chemical kinetics deals with the rate of the reaction at which it occur.

Q: 21. Rate law states that overall order of reaction can be determined by adding the reaction orders…

A: Kindly get the answer given below.

Q: What is the rate-controlling step?

A: Rate controlling step has to be defined.

Q: How does one find the order of reaction?

A: Order of reaction = It is the sum of the power dependence on each concentration of reaction in a…

Q: El E2 Example Reaction Equation Rate Law Energy Diagram Why El or E2? Explain

A: Elimination reaction, any of a class of organic chemical reactions in which a pair of atoms or…

Q: energy reactants Then answer the following questions about the chemical reaction. Does this reaction…

A: A reaction can be endothermic and exothermic depending on the energies of product and reactant. In…

Q: The reaction rate constant may be defined as the rate of the reaction when the concentration of each…

A: Rate of reaction is directly proportional to the product of concentration of reactant each raised to…

Q: Circle the points that should be used to determine the initial rate of the reaction. [reactant] 0…

A: Initial rate:- Initial rate of reaction is the rate t= 0 time. •So we have to mark point in graph at…

Q: Which reaction took place at a greater rate, explain

Q: As the temperature of a reaction is increased, the rate of the reaction increases because the The…

A: A chemical reaction happens when reactant molecule gets collide with each other or we can say…

Q: Catalysts can affect the rate of a reaction. O True O False

A: Given : Catalysts can affect rate of reaction.

Q: order of reaction

A: Reversible reactions are those that in conversion of reactants into products and vice versa occur…

Q: Sketch a qualitative reaction energy diagram for a chemical reaction with and without a catalyst.…

A: Given : We have to draw catalyzed and uncatalyzed curve between energy and reaction coordinates.

Q: How would the reaction rate change if you heat a reaction up? The reaction rate will increase Not…

A: Using concept of Arrhenius equation A= ke-Ea/RT

Q: State two reasons why increasing temperature increases reaction rate.

A: Increasing temperature increases the reaction rate. Two reasons for the above statement have to be…

Q: Collision Theory Gizmo

Q: How a reaction's rate changes with concentration ?

Q: Study the following reaction energy diagram: energy reactants Then answer the following questions…

Question

Please explain how this reaction happens

R
- NH2
NH
HO.
NH
DCC,THF
NH
RT, N2 (atm.)
Вос
*NH2
Вос
`NH2
6(b-e)
R= -CH,CH(CH,),.(2b)
-CH,Ph,(2c)
-CH,CH,-S-CH3,(2d)
Acetone,
72°C,
-Ph,(3e)
8hr.
R
R.
H;PO,(85%)
NH2
THF,RT,24hr.
NH
8(b-e)
Вос
7(b-e)
NCS
Acetone,
reflux
R
NH.
N.
CF3
9(b-e)

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1 Introduction

VIEW

Step 2 Reaction Mechanism

VIEW

Step by step

Solved in 2 steps with 1 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

Q1) What is Rate of reaction? Briefly define factor that influence rate of reaction.
Increasing the temperature of an ENDOthermic reaction a) Will decrease both the rate constant for a reaction and the equilibrium constantb) Will Increase both the rate constant and the equilibrium constant.c) Will increase the rate constant of the reaction but decrease the equilibrium constant.d) Will decrease the rate constant for a reaction but have no effect on the equilibrium constant.
List the factors affecting the rate of reaction.
15. name one factor that can increase the success of reactant collisions. explain how it increases the reaction rate.
What happens to the rate of reaction as the concentration of the reactants increase? decreases?
Outline how and why increasing temperature, concentration, and a catalyst can speed up the rate of a reaction.
Encreasing the temperature increases the rate of a reaction by doing which of the following? Increasing the activation energy, Lowering the activation energy, Increasing the frequency of effective collisions between reacting molecules, Potential energy of the products, Lowering the frequency of effective collisions between reacting molecules
which of the below statement concering the rate of the reaction is NOT true? a. the rate of the reaction depends only on the concentration of the reactants b. the rate of the reaction decreases with decrease in temperature c. catalyst decreases the energy of activation d. the rate of the reaction increases with increase in temperature e. the rate of reaction increases with increase in concentration of reactants
How does increasing temperature affect the rate of reaction? the activation energy increases so the reaction rate decreases the reactants have more kinetic energy so the frequency of the effective collisions increases the reactants have more kinetic energy so the frequency of the effective collisions decreases the activation energy increases so the reaction rate increases
Reaction rate increased by an increase of surface area of a reactant. One way to increase surface area is to add catalyst crush solid reactant into smaller pieces increase reactant's temperature increase reactant's concentration
Help
as the temp of a reaction is increased the rate of the reaction increases why? (see image)