Question 5 Furosemide is a diuretic used in the treatment of congestive heart failure and oedema. 20 tablets of furosemide were powdered and 0.5195 g of powder was weighed out, shaken with 300 mL of NaOH and made up to 500 mL with 0.1 M NaOH. A portion of the extract was filtered and 5 mL of the filtrate was made up to 250 mL with 0.1 M NaOH. The absorbance of the diluted solution was measured at 271 nm. A (1%, 1 cm) value at 271 nm in basic solution Stated content of furosemide Weight of 20 tablets per tablet HN- From the data below calculate the percentage of stated content in a sample of furosemide tablets. (DGW 2005, 103) = 580 = 40 mg = 1,656 g OH NH

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Question 5
Furosemide is a diuretic used in the treatment of congestive heart
failure and oedema. 20 tablets of furosemide were powdered and 0.5195
g of powder was weighed out, shaken with 300 mL of NaOH and made up
to 500 mL with 0.1 M NaOH. A portion of the extract was filtered and 5
mL of the filtrate was made up to 250 mL with 0.1 M NaOH. The
absorbance of the diluted solution was measured at 271 nm.
A (1%, 1 cm) value at 271 nm in basic solution
Stated content of furosemide per tablet
Weight of 20 tablets
Weight of tablet powder taken for analysis
Absorbance reading at 271 nm
From the data below calculate the percentage of stated content in a sample of furosemide
tablets. (DGW 2005, 103)
= 580
HN
40 mg
1.656 g
= 0.5195 g
= 0,596
OH
CI
/
NH₂
Transcribed Image Text:Question 5 Furosemide is a diuretic used in the treatment of congestive heart failure and oedema. 20 tablets of furosemide were powdered and 0.5195 g of powder was weighed out, shaken with 300 mL of NaOH and made up to 500 mL with 0.1 M NaOH. A portion of the extract was filtered and 5 mL of the filtrate was made up to 250 mL with 0.1 M NaOH. The absorbance of the diluted solution was measured at 271 nm. A (1%, 1 cm) value at 271 nm in basic solution Stated content of furosemide per tablet Weight of 20 tablets Weight of tablet powder taken for analysis Absorbance reading at 271 nm From the data below calculate the percentage of stated content in a sample of furosemide tablets. (DGW 2005, 103) = 580 HN 40 mg 1.656 g = 0.5195 g = 0,596 OH CI / NH₂
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