Question 17 ( Here is a step from the citric acid cycle enzyme citrate synthase. His274 s-COA H- s-COA Asp375 Substrate is black and enzyme residues are green. What are the roles of His274 and Asp375 respectively? (Order is important.) Positioning substrate and transition state and an acid A base and a base An electrophile and a base An acid and a base OPositioning substrate and transition state and a base. An electrophile and an acid

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