Q21.15 - Level 1 O Important Homework • Unanswered Which of the following halides cannot be used for Friedel-Crafts alkylation? A 2-Bromopropane Allylchloride Chlorobenzene 1-Chloropropane Hint Remember that a carbocation is generated by the loss of halogen from an sp hybridized carbon.

Answer Q18, 19, 20, 21

Give detailed Solution with explanation needed of both sub parts...don't give Handwritten answer

Answer the following questions based on the information provided. (a) Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension. One of the key step of Sildenafil synthesis is shown below. OEt O OEt O i) Amine HO CHO ii) H20 washing to remove the HCI residue CI N. i) What's the structure of Amine reagent? Amine structure ii) Why does not carboxyl acid react with amine? iii) Draw the mechanism of the reaction.