Propose an efficient synthesis for the given transformation. 8-6 This transformation can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A NaH F 1) MeMgBr; 2) H3O+ K dilute H₂SO4 B 1); 2) H3O+ G Na, NH3 (1) L DMP or PCC C 1) Å ; 2) H3O+ H MCPBA (RCO 3H) M SOCI2, pyridine D Mg I 1) EtMgBr; 2) H3O+ N EtBr E H2, Lindlar's cat. J HBr (xs), heat O 1) BH3-THF; 2) H₂O2, NaOH

THC (tetrahydrocannabinol) is the primary psychoactive component of cannabis. THC is produced from THCA (tetrahydrocannabinolic acid) when THCA is heated (i.e. when cannabis leaves are smoked or cooked). a) Propose a mechanism for the decarboxylation of THCA under acidic conditions. Hint: first the "enol" tautomerizes to the ketone, then decarboxylation occurs. OH THCA OH H3O+ heat OH THC b) Which part of the mechanism do you think occurs more readily: tautomerization to the ketone or decarboxylation? Why?

The Stork reaction is a condensation reaction between an enamine donor and an a,ẞ-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of 1. formation of an enamine from a ketone. 2. Michael addition to an α,ß-unsaturated carbonyl compound, and 3. hydrolysis of the enamine in dilute acid to regenerate the ketone. Consider the Stork reaction between cyclohexanone and propenal. Draw the structure of the product of the enamine formed between cyclohexanone and dimethylamine. ચર્ચ F Correct HC, CH3 ChemDoodle 2 Draw the structure of the Michael addition product. ChemDoodle Jn (F 106 Correct

Give detailed Solution with explanation needed

Propose a two step synthesis for the following compound using the acetylide anion as a starting material (shown below). You may use any other organic compounds or inorganic reagents.

Please give the appropriate reagents to complete the following synthesis. 1.? 2. ?

1. Acetone is more reactive than Ethyl Acetate towards nucleophilic substitution reaction. Give reasons.   HINTS: Ethyl acetate has OEt group, which is in conjugation with the carbonyl, reduces the reactivity.

How to synthesize phenyl methyl bromide?

Propose a synthesis of compound A' from butanal A'

Propose a mechanism for the following transformation Jung