Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Why won't most primary alkyl halides react in Friedel-Crafts alkylation reactions?
O Primary alkyl halides undergo methyl shifts under the standard conditions of Friedel-Crafts alkylation reactions, making
them unreactive.
Primary alkyl halides create primary carbocations which are too high in energy and too readily undergo rearrangement.
Primary alkyl halides do not form a sigma complex after a nucleophilic attack since they connect at the primary carbocation
site.
Primary alkyl halides as a reactant violates one of the three standard limitations to Friedel-Crafts alkylation reactions.
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Transcribed Image Text:Why won't most primary alkyl halides react in Friedel-Crafts alkylation reactions? O Primary alkyl halides undergo methyl shifts under the standard conditions of Friedel-Crafts alkylation reactions, making them unreactive. Primary alkyl halides create primary carbocations which are too high in energy and too readily undergo rearrangement. Primary alkyl halides do not form a sigma complex after a nucleophilic attack since they connect at the primary carbocation site. Primary alkyl halides as a reactant violates one of the three standard limitations to Friedel-Crafts alkylation reactions.
Product
is the major product of
the reduction shown.
Na, CH 3OH
NH3
В
D
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Transcribed Image Text:Product is the major product of the reduction shown. Na, CH 3OH NH3 В D
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