Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
Bartleby Related Questions Icon

Related questions

bartleby

Concept explainers

Question
Number 1 please explain
1. Arrange the steps involved in molecular docking into a proper sequence.
А.
A least squares fit of ligand atoms to the sphere centers is applied to ensure proper
orientation.
В.
Ligand atoms are matched to sphere centers.
The interaction energy is computed as a "Z-score" for binding mode.
The best-scoring orientations are retained for subsequent analysis.
A “negative" image of the binding site is made.
New orientations obtained by matching different sets of atoms and sphere centers.
Orientation is checked for steric clashing between ligand and receptor.
С.
D.
E.
F.
G.
a. A, B, C, E, F, G, D
b. B, A, E, G, C, D, F
c. C, G, B, A, F, D, E
d. E, B, A, G, C, F, D
e. G, E, A, B, F, D, C
2. Carbonic anhydrase has two substrates, carbon dioxide and bicarbonate, which are both
converted to carbonic acid. Kinetic data for each is given below. Typical values for
Kcat/Km range from less than 1 mM-'sec-' to as high as 2.8×10$ mM-'sec-'. What can be
said about the Kcat/Km for CO2?
Substrate
Km (mM)
Kcat (sec-!)
Kca/Km (m M-'sec-!)
8.3x104
1.5x104
12
1x106
CO2
HCO3
26
4x105
a. carbonic anhydrase binds CO2 well but poorly converts it to carbonic acid
b. carbonic anhydrase binds CO2 poorly but effectively converts it to carbonic acid
carbonic anhydrase binds CO2 well and converts it to carbonic acid very well
acid
expand button
Transcribed Image Text:1. Arrange the steps involved in molecular docking into a proper sequence. А. A least squares fit of ligand atoms to the sphere centers is applied to ensure proper orientation. В. Ligand atoms are matched to sphere centers. The interaction energy is computed as a "Z-score" for binding mode. The best-scoring orientations are retained for subsequent analysis. A “negative" image of the binding site is made. New orientations obtained by matching different sets of atoms and sphere centers. Orientation is checked for steric clashing between ligand and receptor. С. D. E. F. G. a. A, B, C, E, F, G, D b. B, A, E, G, C, D, F c. C, G, B, A, F, D, E d. E, B, A, G, C, F, D e. G, E, A, B, F, D, C 2. Carbonic anhydrase has two substrates, carbon dioxide and bicarbonate, which are both converted to carbonic acid. Kinetic data for each is given below. Typical values for Kcat/Km range from less than 1 mM-'sec-' to as high as 2.8×10$ mM-'sec-'. What can be said about the Kcat/Km for CO2? Substrate Km (mM) Kcat (sec-!) Kca/Km (m M-'sec-!) 8.3x104 1.5x104 12 1x106 CO2 HCO3 26 4x105 a. carbonic anhydrase binds CO2 well but poorly converts it to carbonic acid b. carbonic anhydrase binds CO2 poorly but effectively converts it to carbonic acid carbonic anhydrase binds CO2 well and converts it to carbonic acid very well acid
Expert Solution
Check Mark
Knowledge Booster
Background pattern image
Chemistry
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Text book image
Chemistry
Chemistry
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Cengage Learning
Text book image
Chemistry
Chemistry
ISBN:9781259911156
Author:Raymond Chang Dr., Jason Overby Professor
Publisher:McGraw-Hill Education
Text book image
Principles of Instrumental Analysis
Chemistry
ISBN:9781305577213
Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:Cengage Learning
Text book image
Organic Chemistry
Chemistry
ISBN:9780078021558
Author:Janice Gorzynski Smith Dr.
Publisher:McGraw-Hill Education
Text book image
Chemistry: Principles and Reactions
Chemistry
ISBN:9781305079373
Author:William L. Masterton, Cecile N. Hurley
Publisher:Cengage Learning
Text book image
Elementary Principles of Chemical Processes, Bind...
Chemistry
ISBN:9781118431221
Author:Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:WILEY