Please predict the products for each of the following reactions. Hint: one of the reactions is the Friedel-Crafts Acylation. 1. SOCI 2 2. Py (base) HO 1. SOCI₂ 2. LIAIH4 (excess) 3. H₂O 1. SOCI₂ 2. AICI 3 6 8 SOCI₂ 10 10 1. SOCI 2 2. PhMgBr (exce Ο 3. H₂O EtOH, H₂O* heat OH 2 1. SOCI₂ 2. NH3 (excess) 1. SOCI₂ 2. Ph₂CuLi 10 5 1. SOCI₂ 2. ° NH 1. SOCI₂ 2. Et N (base) HO A B с D l be ble la CI NH A B C D

Use the information below to identify and explain the relationship between the basicity of the two nucleophiles and their nucleophilicities

SN1 reactions are better performed in protic solvents. Explain why the researchers could not perform the reaction using 100% water as solvent instead of 50% aqueous acetone.

Propose a reasonable mechanism

18 of 21 60. Select the compound that is not an intermediate in the following organic transformation. ОН НО НО НО ОН ОН ОН А 61. When treated with 0.01 M HCI, molecule _will be protonated to the greatest extent while molecule will be protonated to the least extent. NH2 II IV || O=N* а. 1, I b. III, I C. III, II d. III, IV 62. Identify the mechanistic step in a Claisen condensation with the largest equilibrium constant value. a. initial proton transfer by ethoxide to yield the enolate ion b. nucleophilic attack of the enolate ion on the ester electrophile c. reformation of the carbonyl to promote heterolysis of the alkoxide leaving group d. proton transfer of the alkoxide on the newly formed beta keto ester substrate

1. Provide a complete arrow pushing mechanism for the Wittig reaction starting from the salt that is used as the starting material in the reaction. Make sure to account for all byproducts of the reaction and that the relative stereochemistry on your betaine accounts for the trans product formation.

Please provide mechanism and structures for intermediate A and intermediate B

Just give explanation of the correct option and explanation of the incorrect options no need to upload image. Hand written solutions are strictly prohibited.

15. What is the product, W, of the following reaction sequence? 1 equiv. I COzH i. excess NaOEt ii. Bri IV 1 equiv. HO₂C. OH Br II IV 17. Predict the product of the following reaction sequence. i. NaOC₂H5 ii. CH3CH₂CH₂Br iii. NaOH iv. H3O*, heat iii H30 heat CO₂H OH ? CO₂H OH Ju qe je OH O I II III V W COOH III 16. What would be the major product of the following reaction sequence? OH a) Ethyl acetoacetate b) Ethyl acetoacetate c) Ethyl acetoacetate IV e) Ethyl hexanoate PCC CH₂Cl₂ 18. 2-Heptanone can be synthesized by which reaction sequence? heat, II NaOEt CH3(CH₂) 3 Br EtOH NaOEt EtOH i. dil.OH heat ii. H30 d) Ethyl acetoacetate CH₂(CH₂);Br_ i. LDA ii. C₂H₂I 22 i. NaOEt, EtOH ii. CH3COCI V III NaOEt EtOH i. dil.OH heat ii. H30 CH3(CH₂)3Br CH₂(CH₂), Br i. dil.OH ii. H30¹ heat, i. dil.OH heat_ ii. H30*

1. MgBr 1. Dry ether OH 2. Hао 2. Br AIB 3 AIBra d = Electrophilic addition g = SN1 Nucleophilic a = Proton transfer substitution h = SN2 Nucleophilic b = Lewis acid/base e = El Elimination substitution c = Radical chain f= E2 Elimination substitution Identify the mechanism by which each of the reactions above proceeds from among the mechanisms listed. Use the letters a - i for your answers. 1. 2. Submit Answer Retry Entire Group 8 more group attempts remaining