Please interprete tests results given( for example say whether the different tests are normal or not etc.)and also give a diagnosis , explaination and treatment for the case below . I got this case study for the topic metabolic and endocrine importance of the skeletal muscle so please give a diagnosis relating to this topic if there is one . A 53-year-old woman went to the doctor for pain and muscle weakness in all four limbs for the last two years, which has prevented her from doing moderate physical activity for the last three months. In the anamnesis the doctor observes obesity and the rest normal, when reviewing the medical history he corroborates the aspect of obesity and points out severe persistent asthma treated with steroids and hypothyroidism with treatment. Blood paraclinics: Hb 13.8 g/dL, Fe 72 μg/dL, AST 52 U/L, Leu 7,410 103/μL, CK 2,290 U/l, Plaq. 306 103 /μL, Ca++ 10.5 mg/dL, Cortisol am 7.9 μg/dL, Glc 92 mg/dL, Alb. 4.8 g/dL, ANA negative, Creatinine 1.0 mg/dL, Ferritin 60.8 ng/mL, Na+ 146 mmol/l, HBV and HCV and HIV Negative, PAK 88 U/L, K+ 5. 0mmol/L, ALT 59 U/L, cyanocobalamin 496 pg/mL, H4F Folate 14 ng/mL, TSH 6.06 μUl/mL PTH 75 pg/mL, total OH-vitamin D 75 ng/mL, C3 148 mg/dL and C4 25 mg/dL. Other findings: normal EMG and MRI of quadriceps showed no muscle inflammation. Therefore, it was decided to perform a biopsy of the left quadriceps and these were the histological results: A) Clear subsarcolemmal vacuoles stained with hematoxicillin-eosin, B) Eosinophilic content finely granular positive with PAS staining and C) Histochemical study for myophosphorylase negative.
Please interprete tests results given( for example say whether the different tests are normal or not etc.)and also give a diagnosis , explaination and treatment for the case below . I got this case study for the topic
A 53-year-old woman went to the doctor for pain and muscle weakness in all four limbs for the last two years, which has prevented her from doing moderate physical activity for the last three months. In the anamnesis the doctor observes obesity and the rest normal, when reviewing the medical history he corroborates the aspect of obesity and points out severe persistent asthma treated with steroids and hypothyroidism with treatment.
Blood paraclinics: Hb 13.8 g/dL, Fe 72 μg/dL, AST 52 U/L, Leu 7,410 103/μL, CK 2,290 U/l, Plaq. 306 103 /μL, Ca++ 10.5 mg/dL, Cortisol am 7.9 μg/dL, Glc 92 mg/dL, Alb. 4.8 g/dL, ANA negative, Creatinine 1.0 mg/dL, Ferritin 60.8 ng/mL, Na+ 146 mmol/l, HBV and HCV and HIV Negative, PAK 88 U/L, K+ 5. 0mmol/L, ALT 59 U/L, cyanocobalamin 496 pg/mL, H4F Folate 14 ng/mL, TSH 6.06 μUl/mL PTH 75 pg/mL, total OH-vitamin D 75 ng/mL, C3 148 mg/dL and C4 25 mg/dL.
Other findings: normal EMG and MRI of quadriceps showed no muscle inflammation.
Therefore, it was decided to perform a biopsy of the left quadriceps and these were the histological results: A) Clear subsarcolemmal vacuoles stained with hematoxicillin-eosin, B) Eosinophilic content finely granular positive with PAS staining and C) Histochemical study for myophosphorylase negative.
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