Planning A Grignard Synthesis: (1) Identify the Degree of the Alcohol (2) Identify the Carbonyl Functional Class any (3) Identify the Grignard Reagent-Since a Grignard reagent is a stable carbanions such as MeX, 1°RX and Phx. 98° Sther aldeh 10

Organic Chemistry
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ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter22: Carbonyl Alpha-substitution Reactions
Section22.SE: Something Extra
Problem 64AP: The key step in a reported laboratory synthesis of sativene, a hydrocarbon isolated from the mold...
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The alcohol name is : 2 butanol
Planning A Grignard Synthesis:
(1) Identify the Degree of the Alcohol 18
(2) Identify the Carbonyl Functional Class any Sther aldehudo
(3) Identify the Grignard Reagent- Since a Grignard reagent is a
stable carbanions such as MeX, 1°RX and Phx.
use halides that give rise to
Problem: Give the order of stability of carbanions:
(4) Keep water away from a Grignard reagent- Water
irreversible, corresponding
the alcolate. (5) C6H6MgBr + CO, → A
a Grignard reagent producing the
of the halide and Mg(OH)X equilibrium lies in favor of the alkane and not
A
H30 ->
Propose a synthesls for:
1. (a) 1-ethyl-2-methyl-1-cyclohexanol from2-methylcyclohexanone and the correct Grignard reagent.
Transcribed Image Text:Planning A Grignard Synthesis: (1) Identify the Degree of the Alcohol 18 (2) Identify the Carbonyl Functional Class any Sther aldehudo (3) Identify the Grignard Reagent- Since a Grignard reagent is a stable carbanions such as MeX, 1°RX and Phx. use halides that give rise to Problem: Give the order of stability of carbanions: (4) Keep water away from a Grignard reagent- Water irreversible, corresponding the alcolate. (5) C6H6MgBr + CO, → A a Grignard reagent producing the of the halide and Mg(OH)X equilibrium lies in favor of the alkane and not A H30 -> Propose a synthesls for: 1. (a) 1-ethyl-2-methyl-1-cyclohexanol from2-methylcyclohexanone and the correct Grignard reagent.
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