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Ph OH PCC OH 1. NaBH₁ 2. Dil. H₂O* 1. HSCH₂CH₂CH₂SH AICI 2. BuLi PhCH₂Br HgO/H₂O

Ph OH PCC OH 1. NaBH₁ 2. Dil. H₂O* 1. HSCH₂CH₂CH₂SH AICI 2. BuLi PhCH₂Br HgO/H₂O

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Complete the road map by providing the structures of the products or the reagents as needed
in the boxes provided below. Please note, there may be more than one reagent needed for
some of the steps.

 

This image outlines a multi-step organic synthesis process, starting with phenol compound transformation. 1. **Starting Material**: - Phenol (Ph-OH) 2. **First Reaction**: - Reagent: PCC - Transformation: The alcohol functional group of phenol undergoes oxidation by PCC, yielding a compound in a box (not specified). 3. **Second Reaction**: - Reagents: - 1. HSCH₂CH₂CH₂SH, AlCl₃ - 2. BuLi - This step involves multiple reagents likely for further functional group transformation, using a protecting group mechanism followed by Li-based reagent action, leading to another unspecified intermediate product. 4. **Third Reaction**: - Reagent: PhCH₂Br - The intermediate reacts with PhCH₂Br to incorporate a benzyl group or introduce further aromatic components, transforming into another intermediate. 5. **Fourth Reaction**: - Reagent: HgO/H₂O - The subsequent reaction involves these reagents, possibly indicating an oxidative, hydrolytic, or rearrangement step yielding another intermediate. 6. **Fifth Reaction**: - Intermediate depicted: A ketone with a diphenyl group. - Reagents: - 1. NaBH₄ - 2. Dil. H₃O⁺ - This reaction involves reduction with NaBH₄, indicating the reduction of the ketone to an alcohol. The dil. H₃O⁺ suggests subsequent hydrolysis or quenching. 7. **Final Product**: - A tertiary alcohol featuring phenyl and diphenyl groups. - The structure indicates the synthesis pathway's completed product. Each step involves the strategic use of reagents to achieve the desired transformations, reflecting a common strategy in complex organic synthesis.
Transcribed Image Text:This image outlines a multi-step organic synthesis process, starting with phenol compound transformation. 1. **Starting Material**: - Phenol (Ph-OH) 2. **First Reaction**: - Reagent: PCC - Transformation: The alcohol functional group of phenol undergoes oxidation by PCC, yielding a compound in a box (not specified). 3. **Second Reaction**: - Reagents: - 1. HSCH₂CH₂CH₂SH, AlCl₃ - 2. BuLi - This step involves multiple reagents likely for further functional group transformation, using a protecting group mechanism followed by Li-based reagent action, leading to another unspecified intermediate product. 4. **Third Reaction**: - Reagent: PhCH₂Br - The intermediate reacts with PhCH₂Br to incorporate a benzyl group or introduce further aromatic components, transforming into another intermediate. 5. **Fourth Reaction**: - Reagent: HgO/H₂O - The subsequent reaction involves these reagents, possibly indicating an oxidative, hydrolytic, or rearrangement step yielding another intermediate. 6. **Fifth Reaction**: - Intermediate depicted: A ketone with a diphenyl group. - Reagents: - 1. NaBH₄ - 2. Dil. H₃O⁺ - This reaction involves reduction with NaBH₄, indicating the reduction of the ketone to an alcohol. The dil. H₃O⁺ suggests subsequent hydrolysis or quenching. 7. **Final Product**: - A tertiary alcohol featuring phenyl and diphenyl groups. - The structure indicates the synthesis pathway's completed product. Each step involves the strategic use of reagents to achieve the desired transformations, reflecting a common strategy in complex organic synthesis.
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