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Part 1. Norrie disease is caused by a recessive mutation on the X chromosome in a gene called norrin. The disease affects the eyes and can cause blindness. In the picture below, the left (A) and right (B) retinas from the same female mouse are shown. The X chromosome inherited from the father is labeled magenta and the X chromosome inherited from the mother is labeled yellow. A. B. From this picture, and the information you know about X chromosomes, what can you conclude? Imprinting randomly renders one of these X chromosomes inactive per cell, so this is what you would expect from that process. The maternal chromosome is likely imprinted in the left eye while the paternal chromosome is likely imprinted in the right eye. In the left eye, more of the cells have the paternal chromosome inactivated than in the right eye. In the left eye, more of the cells have the maternal chromosome inactivated than in the right eye.

Part 1. Norrie disease is caused by a recessive mutation on the X chromosome in a gene called norrin. The disease affects the eyes and can cause blindness. In the picture below, the left (A) and right (B) retinas from the same female mouse are shown. The X chromosome inherited from the father is labeled magenta and the X chromosome inherited from the mother is labeled yellow. A. B. From this picture, and the information you know about X chromosomes, what can you conclude? Imprinting randomly renders one of these X chromosomes inactive per cell, so this is what you would expect from that process. The maternal chromosome is likely imprinted in the left eye while the paternal chromosome is likely imprinted in the right eye. In the left eye, more of the cells have the paternal chromosome inactivated than in the right eye. In the left eye, more of the cells have the maternal chromosome inactivated than in the right eye.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Part 1. Norrie disease is caused by a recessive mutation on the X chromosome in a gene called norrin. The disease affects the eyes and can cause blindness. In the picture below, the left (A) and right (B) retinas from the same female mouse are shown. The X chromosome inherited from the father is labeled magenta and the X chromosome inherited from the mother is labeled yellow. А. В. From this picture, and the information you know about X chromosomes, what can you conclude? Imprinting randomly renders one of these X chromosomes inactive per cell, so this is what you would expect from that process. The maternal chromosome is likely imprinted in the left eye while the paternal chromosome is likely imprinted in the right eye. In the left eye, more of the cells have the paternal chromosome inactivated than in the right eye. In the left eye, more of the cells have the maternal chromosome inactivated than in the right eye. Part 2. Given the information in the previous question, if the norrin gene donated by the father has a mutation, and the one donated by the mother does not, what will the result be for these eyes? Both eyes are likely to be nonfunctional (organism is fully blind) The left eye (A) is likely to be nonfunctional (organism is blind in the left eye) The right eye (B) is likely to be nonfunctional (organism is blind in the right eye) Both eyes are likely to be functional (organism is not blind) Part 3. If, rather than looking at a female mouse as shown in parts 1 and 2, you were observing the retina of a normal male mouse, what would you expect to see? Both retinas should be labeled with yellow only. The distribution of magenta and yellow will depend on whether the mouse inherited a mutation. Both retinas will have equal amounts of magenta and yellow label. The retinas could look very similar to the retinas from the female mouse in terms of differing magenta and yellow labels.
Transcribed Image Text:Part 1. Norrie disease is caused by a recessive mutation on the X chromosome in a gene called norrin. The disease affects the eyes and can cause blindness. In the picture below, the left (A) and right (B) retinas from the same female mouse are shown. The X chromosome inherited from the father is labeled magenta and the X chromosome inherited from the mother is labeled yellow. А. В. From this picture, and the information you know about X chromosomes, what can you conclude? Imprinting randomly renders one of these X chromosomes inactive per cell, so this is what you would expect from that process. The maternal chromosome is likely imprinted in the left eye while the paternal chromosome is likely imprinted in the right eye. In the left eye, more of the cells have the paternal chromosome inactivated than in the right eye. In the left eye, more of the cells have the maternal chromosome inactivated than in the right eye. Part 2. Given the information in the previous question, if the norrin gene donated by the father has a mutation, and the one donated by the mother does not, what will the result be for these eyes? Both eyes are likely to be nonfunctional (organism is fully blind) The left eye (A) is likely to be nonfunctional (organism is blind in the left eye) The right eye (B) is likely to be nonfunctional (organism is blind in the right eye) Both eyes are likely to be functional (organism is not blind) Part 3. If, rather than looking at a female mouse as shown in parts 1 and 2, you were observing the retina of a normal male mouse, what would you expect to see? Both retinas should be labeled with yellow only. The distribution of magenta and yellow will depend on whether the mouse inherited a mutation. Both retinas will have equal amounts of magenta and yellow label. The retinas could look very similar to the retinas from the female mouse in terms of differing magenta and yellow labels.
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