Draw step by step the reaction mechanism of the following reaction OTBSIIIOHMe(IIMeOMeOMeOTIPSзатOTIPStBuLi, Et2O, -78 °C83%OTBS(IIIMeMeIT...HOMeOMe

Carbonyl C atom is electron-deficient C atom. Hence, it is electrophilic in nature. An electrophile…

Answered: OTBS I !!! OH Me™! Im Me H OMe OMe…

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OTBS I !!! OH Me™! Im Me H OMe OMe OTIPS Br OTIPS tBuLi, Et₂O, -78 °C 83% OTBS I Me Me I !!!! "H OMe OMe

Chemistry by OpenStax (2015-05-04)

1st Edition

ISBN:9781938168390

Author:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser

Publisher:Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser

Chapter11: Solutions And Colloids

Section: Chapter Questions

Problem 27E: What is the microscopic explanation for the macroscopic behaviour illustrated in Figure 11.15?

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Question

Draw step by step the reaction mechanism of the following reaction

OTBS
III
OH
Me
(II
Me
OMe
OMe
OTIPS
зат
OTIPS
tBuLi, Et2O, -78 °C
83%
OTBS
(III
Me
Me
IT
...H
OMe
OMe

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Step 1: Reactions of carbonyl carbon

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Step 2: Comparing the reactant and product

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Step 3: Generation of nucleophile.

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Step 4: Attack of nucleophile.

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Step 5: Protonation

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