on он 1. НаО, кон 2. H,O, HCI он, + HO, p-cresol chloroacetic acid p-methylphenoxyacetic acid

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
Section: Chapter Questions
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Draw and Explain the reaction mechanism for the Williamson Ether reaction. Cresol is the nucleophilic component of the ether synthesis reaction and chloroacetic acid is the electrophilic component. Due to cresol being weak, a strong nucleophile has to be made before the reaction can begin. A base of KOH is added with cresol so that nucleophile can be strong before it is mixed with chloroacetic acid. 

1. НаО, КоН
2. Н-О, HС
он
HO.
p-cresol
chloroacetic acid
p-methylphenoxyacetic acid
Transcribed Image Text:1. НаО, КоН 2. Н-О, HС он HO. p-cresol chloroacetic acid p-methylphenoxyacetic acid
он
кон
phenol
(weak nucleophile)
phenoxide
(stronger nucleophile)
Transcribed Image Text:он кон phenol (weak nucleophile) phenoxide (stronger nucleophile)
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