Nucleus Cytoplasm Neuron -PrpSc -PrpC A prion protein in the PrpSc conformation comes in contact with a PrpC protein, converting it into a PrpSc protein. - Original PrpSc molecule -PrpSc converted from PrpC The 2 PrpSc proteins bind to 2 PrpC proteins, and convert them to PrpSc Over time, all of the PrpC proteins will be converted to PrpSc proteins. FIGURE 25.9 A proposed molecular mechanism of prion diseases. The PrPSc protein catalyzes the conver- sion of a PrP protein to PrP8*. Over time, the PIPS conformation accumulates to high levels, leading to ONLINE ANIMATION symptoms of the prion disease.
Nucleus Cytoplasm Neuron -PrpSc -PrpC A prion protein in the PrpSc conformation comes in contact with a PrpC protein, converting it into a PrpSc protein. - Original PrpSc molecule -PrpSc converted from PrpC The 2 PrpSc proteins bind to 2 PrpC proteins, and convert them to PrpSc Over time, all of the PrpC proteins will be converted to PrpSc proteins. FIGURE 25.9 A proposed molecular mechanism of prion diseases. The PrPSc protein catalyzes the conver- sion of a PrP protein to PrP8*. Over time, the PIPS conformation accumulates to high levels, leading to ONLINE ANIMATION symptoms of the prion disease.
Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter2: Basic Hematology
Section2.12: Reticulocyte Count
Problem 7RQ
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Where does the prion protein come from?
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