Multistep synthesis of Lidocaine Lab 1) How many grams of starting material do you need? It is given in moles below but how many grams? 2) How to calculate theoretical yield? Part One Method A. Preparation of alpha-Chloro-2,6-dimethylacetanilideCombine 0.033 mol of 2,6-dimethylaniline with 25 mL of glacial acetic acid (or ethyl acetateor THF) and 0.033 mol of alpha-chloroacetyl chloride, in that order, in an appropriately sized Erlenmeyer flask. With the aid of a hot water bath, warm the solution to 40-50°C, remove the flask from the bath, and add a solution of 5 g of sodium acetate trihydrate dissolved in 100 mL of water.

LAB 12: SYNTHESIS OF LIDOCAINE Experimental Procedure Step 2: Preparation of Lidocaine, 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide – Step 1- Preparation of N-(2,6-Dimethylphenyl)chloroacetamide 1. To a pre-weighed 50-ml round bottomed flask, add the pressed-dry amide 1 and re-weigh the flask to get an exact amount of amide 1. 1. measure out 3.0 mL of 2,6- dimethylaniline into a 10-mL graduated cylinder and set aside in your hood. 2. sequentially add 7.5 mL diethylamine, 25 mL toluene and a few boiling stones. Attach a water-cooled reflux condenser to the round bottomed flask. 2. measure out 15-ml of glacial acetic acid and add it to a 125 mL Erlenmeyer flask. 3. Reflux the reaction mixture for 60 min. 3. Add the amine (2,6- dimethylaniline), via a Pasteur pipet, to the acetic acid in the Erlenmeyer flask. 4. Cool to room temperature, Transfer to a separatory funnel and wash the organic layer with 3x50 mL portions of 4. Transfer 2 mL of 2-chloroacetyl chloride to the Erlenmeyer…

Sodium borohydride (NABH4) is a very selective reagent. Which functional groups can sodium borohydride reduce? Choose all that apply. O 1. Aldehyde II. Ester III. Carboxylic Acid O IV. Ketone

What is the ratio of benzaldehyde to thiamine hydrochloride used in this reaction? Why are we not using a full equivalent of this reagent?

CH3CH2CH2CH2Cl   + 1) KCN 2) LiAlH4 3) H2O yields ___________.     cyclopentylnitrile     pentan-1-amine     butan-1-nitrile     pentan-1-nitrile     1-chloro-butan-1-nitrile Thank you!

glowe OMe Selected Answer: Answers: 1. HO 2. EtMgBr 3. H3O+ 1. HOT 2. EtMgBr 3. NaOH EtMgBr, followed by aqueous workup 1. HO 2. EtMgBr 3. H3O+ ? 1. LIAIH4 2. EtMgBr 3. NaOH OH OH OH OH O OMe

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8. N-Phenethylmorphine was synthesised from morphine and found to have enhanced activity. Why does N-phenethylmorphine have higher activity than morphine? lina> HO HO HO но Morphine NPhenethymorphine a Increased binding to an extra binding region by van der Waals interactions. b. Increased binding to an extra binding region by hydrogen bonding c. Increased binding to an extra binding region by covalent bonding d. Increased binding to an extra binding region by ionic bonding

Synthesis of Dilantin by Multi-Step Synthesis Part 4 - Ureabenzil Condensation Table of Reagents Molecular weight (g/mol) Mass (g) Volume (mL) density (g/mL) Amount (mmol) Reagent benzil 210.23 1.0 4.75 Sodium hydroxide (30% wv) 39.997 1.2 loo urea 0.432 7,19 - Limiting Reagent: Identify the limiting reagent (warning, some reagents may be catalysts, and can be used in sub- stoichiometric amounts, and not all reactions have 1:1 stoichiometric coefficients) Yield of Product: Calculate the % yield of product you obtained. Watch significant figures and SHOW YOUR WORKING. Overall yield of product based on benzaldehyde: Calculate the % yield of the product you obtained based on the starting material for this synthesis, benzaldehyde. Watch significant figures and SHOW YOUR WORKING.

What compound results from the reaction below? NH₂ quaternary ammonium salt (three CH3I add to analine) primary amine amide nitrous acid CH3I (excess) ammonia