Many transcriptional activators are proteins with a DNA-binding domain (DBD) and an activation domain (AD). Explain how each domain contributes to transcriptional initiation. Would you expect repressors to also have each of these domains?

Using the transcription unit diagrammed below, in which exons are represented by blue boxes and introns are represented by the connecting lines.  You discover a single base deletion in region E of this DNA sequence. Regarding transcription, this mutation will likely: 1.) Result in an alteration to the mRNA sequence. 2.)Have no effect on transcription or the mRNA sequence 3.)Prevent transcription at the TATAA box 4.) Result in an increase or decrease in the amount of mRNA transcribed

Because DNA is found in the nucleus, transcription is a nuclear-localized process. Ribosomes responsible for protein synthesis are found in the cytoplasm. Why is hnRNP trafficking to the cytoplasm restricted to the nuclear pore complexes?

The RB (retinoblastoma) protein normally                             [ Select]     ["keep a transcription factor in an inactive state", "keep a transcription factor in an active state", "keep the CDK in a phosphorylated state", "block the function of the APC"]  ...But it can be deactivated by                             [ Select ]                           ["ubiquitination", "methylation",  "phosphorylation", "the use of a GAP"] .Mutations in Rb can lead to cancer because these mutations   [ Select ]                           ["result in constitutive transcription leading to  promotion of the cell cycle",  "keep CDKs off",  "deactivate p53",  "increase the production of growth hormones"]              PLEASE SELCET THE CORRECT ONE FOR SECTION ONE . EACH SENTECNE HAVE 4 SECTION TO PICK FROM.