Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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Malate is converted to oxaloacetate by the enzyme malate dehydrogenase in the
final reaction of the citrate cycle. This redox reaction results in the reduction of
NAD+ to generate NADH + H+. Answer the three questions below and choose the
correct answer.
(a) Calculate the delta AE for the malate dehydrogenase reaction.
(b) Calculate AG and determine if the conversion from malate to oxaloacetate is
favorable under standard biochemical conditions using the information below.
(c) Under cellular conditions is the AG favorable or unfavorable?
Oxaloacetate + 2H* + 2e- --> Malate
E° = -0.17 V
NAD* + H+ + 2e- --> NADH
E°' = -0.32 V
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Transcribed Image Text:Malate is converted to oxaloacetate by the enzyme malate dehydrogenase in the final reaction of the citrate cycle. This redox reaction results in the reduction of NAD+ to generate NADH + H+. Answer the three questions below and choose the correct answer. (a) Calculate the delta AE for the malate dehydrogenase reaction. (b) Calculate AG and determine if the conversion from malate to oxaloacetate is favorable under standard biochemical conditions using the information below. (c) Under cellular conditions is the AG favorable or unfavorable? Oxaloacetate + 2H* + 2e- --> Malate E° = -0.17 V NAD* + H+ + 2e- --> NADH E°' = -0.32 V
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