Klunk et al. (2022) recently completed a genome-wide association study (GWAS) using ancient DNA to find genes associated with survival of the medieval bubonic plague pandemic. They found that a C/T polymorphism at SNP rs2549794 near the ERAP2 gene was significantly associated with survival during the plague pandemic. Frequency of the C allele at rs2549794 was significantly higher in individuals who survived the plague than in individuals who died from the plague. (See the figure below.) ERAP2 encodes a protein that functions in immune responses. Which of the following is the best conclusion from these data? a b с d The C allele at SNP rs2549794 made people more susceptible to the plague. d The C allele at SNP rs2549794 made people less likely to die from the plague. C allele frequency 0.81 0.7- Selected answer will be automatically saved. For keyboard navigation, press up/down arrow keys to select an answer. 0.6 0.5 ERAP1/ERAP2: rs2549794 0.4 0.3- ERAP 2 alleles containing a C at SNP rs2549794 made people more susceptible to the plague. ERAP 2 alleles containing a C at SNP rs2549794 made people less likely to die from the plague. BD After BD

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations…