Januvia, the trade name for sitagliptin, was introduced in 2006 for the treatment of type 2 diabetes. (a) Explain why the five-membered ring in sitagliptin is aromatic. (b) Determine the hybridization of each N atom. (c) In what type of orbital does the lone pair on each N atom reside? sitagliptin CF3

Januvia, the trade name for sitagliptin, was introduced in 2006 for the treatment of type 2 diabetes. (a) Explain why the five-membered ring in sitagliptin is aromatic. (b) Determine the hybridization of each N atom. (c) In what type of orbital does the lone pair on each N atom reside? sitagliptin CF3

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter4: Organic Compounds: Cycloalkanes And Their Stereochemistry

Section4.SE: Something Extra

Problem 54AP: As mentioned in Problem 3-53, the statin drugs, such as simvastatin (Zocor), pravastatin...

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