Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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**Cancer Biology Educational Page**

### Fill in the Blanks:

1. **________________** is cancer of glandular cells of the breast epithelium.
2. **________________**, are molecules capable of eliciting an immune response.
3. **COL1A1PDGF** is an example of a **_______________** protein that functions as a growth factor oncogene.
4. Oncogenes show a **_______________** of mutations, while tumor suppressor genes show a **________________** of mutations.
5. **________________** is the process by which a cell can break through the basement membrane and exits the blood vessel.
6. **________________** are tiny clumps of cancer cells that can be dormant for long periods of time.
7. **___________** and **________________** are the two genes involved in familial breast cancer.
8. **________________** is a chemical used as therapy in breast cancer that is both an agonist and antagonist in breast cancer.
9. **________________** is a type of therapy that can act anywhere in the body, or in other words its action is systemic.
10. Resveratrol is the chemical that is found in **________________** with purported cancer prevention capabilities by its action as an antioxidant.

### True/False Questions:

11. Uncontrolled cell proliferation can mean fast or rapid cell proliferation which is one of the characteristics of cancer (True/False)
12. While tobacco acts on the first stage of carcinogenesis (initiation), alcohol acts on the second stage of carcinogenesis (promotion) and thereby both taken together can cause a synergistic effect on carcinogenesis (True/False)
13. Evidence suggests that cancer cells are polyclonal in origin (True/False)
14. PSA is a tumor-associated antigen that is used as a target for prostate cancer therapy (True/False)
15. Increasingly poor differentiation of cells is usually associated with a higher aggressiveness of cancer cells (True/False)
16. In leukemias, Abl on chromosome 9 fuses with IgG gene on chromosome 22 and is thereby converted to an oncogene (True/False)
17. The molecular switches in signaling pathways are phosphate groups that either activate or inactivate a protein (True/False)
18. p53 gene arrests the cell cycle, facilitates the transcription of DNA repair genes, and promotes apoptosis (True/False)
19. Colon cancer is only one of the cancers for which the genetic path to carcinogenesis has been mapped (True
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Transcribed Image Text:**Cancer Biology Educational Page** ### Fill in the Blanks: 1. **________________** is cancer of glandular cells of the breast epithelium. 2. **________________**, are molecules capable of eliciting an immune response. 3. **COL1A1PDGF** is an example of a **_______________** protein that functions as a growth factor oncogene. 4. Oncogenes show a **_______________** of mutations, while tumor suppressor genes show a **________________** of mutations. 5. **________________** is the process by which a cell can break through the basement membrane and exits the blood vessel. 6. **________________** are tiny clumps of cancer cells that can be dormant for long periods of time. 7. **___________** and **________________** are the two genes involved in familial breast cancer. 8. **________________** is a chemical used as therapy in breast cancer that is both an agonist and antagonist in breast cancer. 9. **________________** is a type of therapy that can act anywhere in the body, or in other words its action is systemic. 10. Resveratrol is the chemical that is found in **________________** with purported cancer prevention capabilities by its action as an antioxidant. ### True/False Questions: 11. Uncontrolled cell proliferation can mean fast or rapid cell proliferation which is one of the characteristics of cancer (True/False) 12. While tobacco acts on the first stage of carcinogenesis (initiation), alcohol acts on the second stage of carcinogenesis (promotion) and thereby both taken together can cause a synergistic effect on carcinogenesis (True/False) 13. Evidence suggests that cancer cells are polyclonal in origin (True/False) 14. PSA is a tumor-associated antigen that is used as a target for prostate cancer therapy (True/False) 15. Increasingly poor differentiation of cells is usually associated with a higher aggressiveness of cancer cells (True/False) 16. In leukemias, Abl on chromosome 9 fuses with IgG gene on chromosome 22 and is thereby converted to an oncogene (True/False) 17. The molecular switches in signaling pathways are phosphate groups that either activate or inactivate a protein (True/False) 18. p53 gene arrests the cell cycle, facilitates the transcription of DNA repair genes, and promotes apoptosis (True/False) 19. Colon cancer is only one of the cancers for which the genetic path to carcinogenesis has been mapped (True
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