In the lungs what is the occurring with respect to the [H+] of the microenvironment of the red blood cells to aid in oxygen transport? Select all that apply BPG binding causes the release of protons from the central cavity of the R-state that favors quaternary shift to the T-state Carbamates are forming, causing ionization of protons that leads to [H+] decrease and stabilization of oxygenated Hb Large amounts of bicarbonate being produced, leads to a decrease in pH and stabilization of the T-state of Hb Bicarbonate is picking up protons from Hb as it transtions to the R-state, combating the decrease in the [H+]

select the BEST answer Aconitase is most interesting in that it: Can be coded for by 2 different genes O Exists as either a membrane bound or soluble protein depending on intracellular conditions O Has 2 distinct roles depending on the availability of Iron O Can change the AGº' of it's reaction O Is itself an allosteric regulator of the PDH complex

Give typed explanation of both otherwise leave it

Autophagy Is Required for PKA Activation and Cell Viability upon GlucoseStarvation. The functional relationship between PKA and autophagyis largely unclear. Because PKA controls cell metabolism particularly related to glucose status (21–23), we first examined the relationship between autophagy and PKA activity in the control of cellmetabolism with glucose limitation. We found that in addition toactivating autophagy, glucose starvation also induced the phosphorylation of cAMP response element-binding (p-CREB), a wellknown PKA substrate, indicative of elevated PKA activity in bothHEK293T and HCT116 cells. In contrast, disruption of autophagyby deletion of essential autophagy gene Atg7 or Atg14 abolished theincrease of p-CREB levels in the above cells (SI Appendix, Fig.S1 A, B, D, and E), suggesting that inactivation of autophagy suppresses PKA activity in response to energy shortage. Moreover, lossof Atg7 or Atg14 accelerated cell death in response to glucosestarvation (SI Appendix, Fig.…