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In randomized, double-blind clinical trials of a new vaccine, rats were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose, 111 of 670 subjects in the experimental group (group 1) experienced drowsiness as a side effect. After the second dose, 68 of 551 of the subjects in the control group (group 2) experienced drowsiness as a side effect. Does the evidence suggest that a higher proportion of subjects in group 1 experienced drowsiness as a side effect than subjects in group 2 at the α=0.05 level of significance?
a. Find the test statistic for this hypothesis test. Round to two decimal places as needed.
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- A large clinical trial of the effect of diet on breast cancer assigned women at random to either a normal diet or a low-fat diet. To check that the random assignment did produce comparable groups, we can compare the two groups at the start of the study. Asked if there is a family history of breast cancer: 1276 of the 5964 women in the low-fat group and 1507 of the 7726 women in the control group said "Yes." If the random assignment worked well, there should not be a significant difference in the proportions with a family history of breast cancer. How significant is the observed difference? State: Is there evidence of a difference in the proportion of women with a family history of breast cancer between the treatment and control groups? Plan: Let pi be the proportion for the treatment group, and Pz the proportion for the control group. State the hypotheses for your test. Ha:Pi + P2 Solve: Give the value of the test statistic. Use the calculator. Select an answer ♥ Ho:pi = p2 What is the…arrow_forwardIn randomized, double-blind clinical trials of a new vaccine, children were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose, 125 of 746 subjects in the experimental group (group 1) experienced fever as a side effect. After the second dose, 82 of 627 of the subjects in the control group (group 2) experienced fever as a side effect. Does the evidence suggest that a higher proportion of subjects in group 1 experienced fever as a side effect than subjects in group 2 at the a= 0.01 level of significance? Find the test statistic for this hypothesis test. (Round to two decimal places as needed.)arrow_forwardA clinical trial is conducted to compare an experimental medication to placebo to reduce the symptoms of asthma. Two hundred participants are enrolled in the study and randomized to receive either the experimental medication or placebo. The primary outcome is self-reported reduction of symptoms. Among 100 participants who receive the experimental medication, 38 report a reduction of symptoms as compared to 21 participants of 100 assigned to placebo. When you test if there is a significant difference in the proportions of participants reporting a reduction of symptoms between the experimental and placebo groups. Use α = 0.05. What should the researcher’s conclusion be for a 5% significance level? Reject H0because 2.64 ≥ 1.960. We have statistically significant evidence at α = 0.05 to show that there is a difference in the proportions of patients reporting a reduction in symptoms. We reject H0 at the 5% level because 2.64 is greater than 1.96. We do have statistically…arrow_forward
- In a clinical trial of Nasonex, 300 allergy patients were randomized into two groups, with Group 1 receiving the Nasonex drug (200 mg) and Group 2 receiving a placebo. The experimenter used a 2:1 randomization plan so that more subjects would be assigned to the Nasonex group. One outcome of interest is the incidence rate of headache as a side-effect. Of the 200 patients randomized to the Nasonex group, 52 (or 26%) reported experiencing a headache; and of the 100 patients randomized to the placebo group, only 22 (22%) reported a headache. 1. The makers of Nasonex are concerned that their allergy medication might increase the incidence of headaches. So they would like to assess the claim that the incidence rate of headaches is higher for Nasonex users as compared to placebo. So the null hypothesis is given by H0: p1 - p2 = 0. Select the appropriate alternative hypothesis. Ha: p1 - p2 ≠ 0 Ha: p1 - p2 > 0 Ha: p1 - p2 < 0 2. It seems that the sample sizes of 200…arrow_forwardester Hollar is vice president for human resources for a large manufacturing company. In recent years, he has noticed an increase in absenteeism that he thinks is related to the general health of the employees. Four years ago, in an attempt to improve the situation, he began a fitness program in which employees exercise during their lunch hour. To evaluate the program, he selected a random sample of eight participants and found the number of days each was absent in the six months before the exercise program began and in the six months following the exercise program. Below are the results. Employee Before After 1 6 5 2 6 2 3 7 1 4 7 3 5 4 3 6 3 6 7 5 3 8 6 7 At the 0.05 significance level, can he conclude that the number of absences has declined? Estimate the p-value. State the decision rule for 0.05 significance level. (Round your answer to 3 decimal places.) Compute the test statistic. (Round your answer to 3 decimal places.)arrow_forwardIn randomized, double-blind clinical trials of a new vaccine, monkeys were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose, 117 of 750 subjects in the experimental group (group 1) experienced drowsiness as a side effect. After the second dose, 74 of 631 of the subjects in the control group (group 2) experienced drowsiness as a side effect. Does the evidence suggest that a higher proportion of subjects in group 1 experienced drowsiness as a side effect than subjects in group 2 at the a = 0.05 level of significance? Determine the P-value for this hypothesis test. (Round to three decimal places as needed.) Interpret the P-value. If the population proportions are one would expect a sample difference proportion the one observed in about out of 1000 repetitions of this experiment. (Round to the nearest integer as needed.) State the conclusion for this hypothesis test. A. Reject Ho.…arrow_forward
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