In humans, the gene for tongue rolling (R) is dominant to non-rolling (r). A man homozygous for rolling marries a woman who cannot roll her tongue. Predict the possible genotypes and phenotypes of their children.
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- 8. Huntington’s disease is a degenerative disease of the nervous system that strikes in middle age. The allele that causes the disease (H) is dominant to the allele that results in the normal condition (h). Answer the following questions about the inheritance of this disease. A. What is the genotype of a man who is normal but whose father had Huntington’s disease? B. What is the genotype of a woman who has Huntington’s disease if both of her parents had Huntington’s disease? C. If a man who is heterozygous for Huntington’s disease marries a woman who is normal, what would you expect for the genotypes and phenotypes of their children? D. If a normal man marries a woman who is homozygous for Huntington’s disease, what do you expect for the genotypes and phenotypes of their children?5. A woman with type AB blood marries a man with type homozygous type B blood. What are the phenotype and genotype ratios of the offspring? 6. Hemophilia is a sex linked recessive trait. If a carrier woman marries a normal man. The couple gives birth to a boy. What are the chances that this child will have hemophilia? Make sure use XX or XY here) 7. The height of a certain plant is a result of polygenic inheritance involving two pairs of genes. Draw a Punnett square to show the result of a cross between a tall (AABB) plant and a short (aabbi. What is the phenotype ratio? 8. What is a mutation? 9. What is sickle cell anemia? 10. What is hemophilia? 11. What is a pedigree? 12. Draw a pedigree to represent the following. Shaded symbols should represent individuals with hemophilia: A man with hemophilia marries a normal woman. They have 3 children, two normal boys and a girl who is a carrier. The girl marries a normal man and they have two boys and two girls. One of the girls is a carrier…5. A female child, Della, has the autosomal dominant condition of polydactyly. Della's mother has the normal number of fingers and toes like her parents and brother (Della's maternal grandparents and uncle). Della's father has six fingers on each hand and so did two of his three sisters and his mother (Della's paternal aunt and grandmother). Della has a younger brother who has the normal number of fingers and toes. Give the genotype of each parent and each child. Della's Mother Della's Father Della Della's Brother 5. Draw a pedigree demonstrating polydactyly in the family above. 7
- 8. Consider the following phenotype for hemophilia, a recessive X-linked blood clotting disorder, in decendents of Queen Victoria. Victoria is thought to have been a carrier for the recessive hemophilia allele. What is the probability that Princess Irene is also a carrier? Albert Victoria (1819–1901) Edward Empress Victoria Leopold Princess O O L Duke of Alice Helena Beatrice II of Hesse Christian Albany Kaiser George Princess Frederick (Alexandra) Victoria Leopold Maurice Eugenie Alice Wilhelm II V Irene Alix Tsarina of Athlone Nikolas II (wife of Alfonso XIII)4. Mr. Salazar has Type A blood while Mrs. Salazar has Type B. They have four children. Bobbie has Type A, Gabbie has Type B, Alex has Type AB, and Teddie has Type O. What are the genotypes of all six people in this family? NOTE: The ABO blood type gene has three alleles. IA and IB are codominant; i (for Type O) is recessive to both.2. Can a color-blind female have a son that has normal vision? Color blindness is caused by a sex-linked recessive allele. Explain. Do the Punnett square. *use N = normal vision and n = color blind over X and Y chromosomes. 3. Muscular dystrophy is a sex-linked trait. What parental genotypes could produce a female with=muscular dystrophy? Do the Punnett square. *use M = normal muscles, and m = muscles missing dystrophin protein over X and Y chromosomes. 4. In humans, red-green color-blindness is due to a recessive gene X^c. Normal vision results from the dominant gene X^c. If a homozygous woman of normal vision marries a color-blind man, what type of vision will be expected in their children?
- 7. The ability to roll your tongue (R) is dominant to lack of this ability (r). A. What is the genotype of a man who can roll his tongue if his father couldn’t? B. If a man who is heterozygous for tongue rolling marries a woman who is heterozygous, what would you predict for the genotypes and phenotypes of their children?12. Hemophilia is an x-linked disease in which the blood does not clot normally; it is sometimes called “bleeder’s disease.” Hemophilia is caused by a recessive allele (h). The dominant allele (H) produces blood that clots normally. A. What is genotype of a man who is a hemophiliac? B. What is the genotype of a man with normal blood clotting? C. What is the genotype of a woman with normal clotting blood if her father was a hemophiliac? D. If a man with normal clotting blood and a heterozygous woman have children together, what would you expect for the genotypes and phenotypes of the children?6. In humans, hemophilia is a recessive and sex-linked character. A man and a woman (grandparents), both normal with respect to blood clotting have: 1 a hemophilic son who has a daughter who is normal; - a daughter who has normal blood and who has one hemophilic and one normal son; and - another daughter with normal blood who has five sons, all normal. What are the probable genotypes of grandparents, children, and grandchildren?
- 1. Hemophilia is a disease inherited as a X-linked recessive trait while pattern baldness is controlled by an autosomal gene that is dominant in males and recessive in females. A hemophilic man who is also homozygous for baldness has children with a woman who is not hemophilic but a carrier and heterozygous normal-haired. Show the parental genotypes, the Genotypic ratio (GR) of the offspring and their phenotypic ratio. Separate the total number of the male offspring from female offspring. For example, if there are 8 total number of offspring, count how many are females and how many are males. So if there are 4 females, then the denominator for the genotypic ratio and phenotypic ratio for female offspring is 4. You can convert it to percentage if you want. Answer the following: a. Among the female offspring, what is the probability of having hemophilic but normal haired child? b. Among the male offspring, what is the chance of having a child with normal blood clotting but bald?6. A man with type B blood marries a woman with type A blood. They have the first child with bloodtype O.a. What are the genotypes of the father and the mother?b. What is the genotype and phenotype of the baby? 7. A man with type O blood marries a woman with type AB blood. What is the predicted genotypicand phenotypic ratios of their children?5. Sickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States. (a) Calculate the frequency of the normal and carries of the sickle cell condition. (b) (b) Malaria is a disease caused by a parasite that infects healthy red blood cells and can lead to death. However, the parasite is not able to infect sickle cell red blood cells. Scientists claim that the higher frequency of sickle cell carriers is due to the presence of malaria. Provide reasoning to support the claim.