Answered: In chickens, a key gene involved in sex…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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In chickens, a key gene involved in sex determination has recently
been identified. Called DMRT1, it is located on the Z chromosome
and is absent on the W chromosome. Like SRY in humans, it is
male determining. Unlike SRY in humans, however, female chickens
(ZW) have a single copy while males (ZZ) have two copies of
the gene. Nevertheless, it is transcribed only in the developing testis.
Working in the laboratory of Andrew Sinclair (a co-discoverer
of the human SRY gene), Craig Smith and colleagues were able
to “knock down” expression of DMRT1 in ZZ embryos using RNA
interference techniques (see Chapter 18). In such cases, the developing
gonads look more like ovaries than testes [Nature 461: 267
(2009)]. What conclusions can you draw about the role that the
DMRT1 gene plays in chickens in contrast to the role the SRY gene
plays in humans?

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