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Immunocompromised patients are at a higher risk of cancer. Discuss how the immune system plays a role in this.
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- Explain why immunosupressive therapy is important for transplant patients. In your answer, be sure to discuss the cellular mechanisms of the immune response that can cause problems for the patient (e.g. what are the T cells doing when they encounter transplanted tissue? ect.), as well as potential side effects of long-term therapy for these patients.Describe the cancer immunotherapy that won the Nobel Prize in 2018. Please include: how they discovered the mechanism of action describe the mechanism of action what drug did they developedIn the event of an inflammation in the body, discuss the vaccine concept after indicating how the proteins that cause this formation in the cell where the inflammation occurs and therefore cause the initiation of the fight against this foreign substance.
- Topic: A patient was diagnosed with lymphoma in 2019. The tumor metastasized to multiple sites of the body. In 2020, the same patient was infected with COVID-19. Upon recovery from the infection, the physician performed a CT scan and noticed tumor complete remission. Using your knowledge in immunology, can you described what may have accounted for the complete remission?Statement: In Yescarta treatment, the patient receives modified T-cells from a family member. Is this statement true or false?Briefly describe how the human immunodeficiency virus type-1 (HIV-1) causes immunodeficiency associated with the development of Acquired immune deficiency syndrome (AIDS).
- Please give details about an immune system problem, for example bee sting allergy, food allergy, the flu, COVID-19, etc). Explain something that is special interest about this immune system problem. give detail about what caused it and what symptoms will occur. give a description of the disease, explain the physiology of what someone would experience with this disease please give as much detail as you cannot apart of a graded assignment****You are an oncologist at a local medical center and you have 3 patients with various types of lung cancer. You evaluate the cell surface markers of the cancer cells from each patient using a technique called immunohistochemistry. Which of the following patients is most likely to respond to immunotherapy (i.e. the immunotherapy is likely to work to target cancer cells)? Patient 1: PDL-1 is 0% Patient 2: PDL-1 is 10% Patient 3: PDL-1 is 20%Tumour associated macrophages (TAMS) represent up to 50% of cells in solid tumours. Explain how these cells contribute to immunosuppression in the tumour microenvironment and how they help tumour cells to evade anti-tumour immune responses
- Explain why Kaposi’s sarcoma is more common inimmunocompromised patients.Neoplastic cells typically evade immunosurveillance. Explain how this occurs and describe how targeting tumour-mediated immune suppression has led to novel cancer immunotherapeuticsDefine the term immunological surveillance, and identify the cells involved in this function.