Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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### Question: 

If you wanted to decrease the deltaG of an enzyme-catalyzed reaction and could make only one change, which one of the following would be most likely to be successful?

1. Greatly increase the reaction volume.
2. Use an isozyme with a much higher Km.
3. Find a way of decreasing the concentration of the product (e.g. by consuming that product in another reaction).
4. Greatly increase the enzyme concentration.
5. Add a competitive inhibitor.

(Note: Options are represented in bullet points.)

### Explanation:

This question is related to enzyme kinetics and thermodynamics. DeltaG, or Gibbs free energy change, is a key concept in biochemistry that determines the spontaneity of a reaction. Understanding the factors affecting enzyme activity and how to modulate deltaG can help in various biochemical applications.

### Answer:

The correct choice here would be selected based on the best strategy to achieve the decrease in deltaG for the enzymatic reaction. Analyzing enzyme behavior, product concentration, and inhibitor mechanisms are crucial for this understanding.

---

This transcription is for educational use and aims to provide clarity on how to approach enzyme-catalyzed reaction modifications.
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Transcribed Image Text:### Question: If you wanted to decrease the deltaG of an enzyme-catalyzed reaction and could make only one change, which one of the following would be most likely to be successful? 1. Greatly increase the reaction volume. 2. Use an isozyme with a much higher Km. 3. Find a way of decreasing the concentration of the product (e.g. by consuming that product in another reaction). 4. Greatly increase the enzyme concentration. 5. Add a competitive inhibitor. (Note: Options are represented in bullet points.) ### Explanation: This question is related to enzyme kinetics and thermodynamics. DeltaG, or Gibbs free energy change, is a key concept in biochemistry that determines the spontaneity of a reaction. Understanding the factors affecting enzyme activity and how to modulate deltaG can help in various biochemical applications. ### Answer: The correct choice here would be selected based on the best strategy to achieve the decrease in deltaG for the enzymatic reaction. Analyzing enzyme behavior, product concentration, and inhibitor mechanisms are crucial for this understanding. --- This transcription is for educational use and aims to provide clarity on how to approach enzyme-catalyzed reaction modifications.
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