If the Cori Cycle was operating as part of lactate recycling, would the pentose phosphate pathway need to be operational to supply electrons in the form of NADPH for the biosynthesis of glucose in the liver?
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- If the Cori Cycle was operating as part of lactate recycling, would the pentose phosphate pathway need to be operational to supply electrons in the form of NADPH for the biosynthesis of glucose in the liver? a)No, gluconeogenesis is anabolic, but relies on the reversible reaction of glyceraldehyde 3-phsophate dehydrogenase for both glycoysis and gluconeogenesis; therefore, NADH supplies the electrons b)yes, gluconeogenesis is anabolic and NADPH is the sole source of electrons for any biosynthesismatch the cofactor with its function in the citric acid cycle by entering the number corresponding with the function. A given function may be used more than one time or not at all. Use from the following list of functions to fill in the table below: carries O2 carries small carbon-containing molecules carries e- carries small nitrogen-containing molecules Cofactor Function NAD+/NADH FAD/FADH2 CoA thiamine biotinOf the 36 molecules of ATP produced by the complete metabolism of glucose, how many are produced directly in glycolysis alone, that is, before the common pathway?
- Phosphofructokinase is considered to be the enzyme responsible for controlling the rate-limiting step of the glycolytic pathway. Why would this step be considered rate-limiting step? Explain with reference to the feedback mechanisms that are occurring in cell respiration.During periods of intense physical exercise, the demand for ATP in muscle tissue increases dramatically. L-lactic acid fermentation accounts for almost all of the ATP production in rabbit leg muscle and turkey flight muscle, respectively. A pair of processes, phosphoglycerate kinase and pyruvate kinase, are involved in the formation of ATP during the payout phase of glycolysis. Assume that the enzyme lactate dehydrogenase is absent from skeletal muscle. Could it withstand rigorous physical activity, that is, could it create large amounts of ATP at a rapid pace via the process of glycolysis? Explain.How many total moles of ATP are created in a cell with an ATP synthase with 8 c subunits for every 28 moles of glucose that is completely oxidized in glycolysis and the Krebs cycle? Assume that NADH is transported by the malate aspartate shuttle.
- Please explain the concept of a "feed-forward" mechanism and provide an example of this in the glycolytic pathway.In the Cori cycle, the lactate product of glycolysis in muscle is transformedback into glucose by the liver. (a) List the enzymes involved in the lactate → glucose pathway. (b) What is the net gain/loss of ATP for one round of the Cori cycle (glucose → lactate → glucose)?The reaction catalyzed by citrate syn- thase, shown on the right, is the first step of the TCA cycle. In glycolysis, two key reactions to produce ATP occur because an unfavorable reaction is coupled to another reaction that is thermodynamically favorable. The reaction catalyzed by citrate synthase, shown on the right, is similarly coupled to an unfavorable reac- tion in the TCA cycle. Write the unfavorable reaction using structural formulas and write the key step that drives the two coupled reactions forward. What is the overall AG'o of the coupled reactions? CH3-C >=0 + S-COA Acetyl-CoA 0-C-COO- CH₂-COO Oxaloacetate H₂O COA-SH J citrate synthase CH₂-C HỌ—C—COO SO CH₂-COO Citrate AG'= -32.2 kJ/mol
- If 12 molecules of glucose enter the glycolytic pathway, how many ATP molecules can be generated in the electron transport chain from the NADH produced in the pathway assuming that there are 10 c subunits in the Fo complex of the organism?Describe the mechanism in which NADH is involved in the activation of oxygen molecules in fatty acid desaturation processes.In order to metabolize lactose, most infants express the enzyme lactase in their intestines. How many pyruvate molecules and NADH molecules can be generated in glycolysis from one lactose molecule? Please explain. How many ATP molecules will be used and generated by 1 lactose molecule? Please explain.