If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon be lost as CO,? Ethanol is converted into acetyl CoA by oxidation of the alcohol, first to acetaldehyde, then to acetate followed by activation to form acetyl CoA. For the following answers, the first round refers to the round of the CAC immediately upon entry by the acetyl CoA. O In the first round exclusively at isocitrate dehydrogenase O in the first round exclusively at a-ketoglutarate dehydrogenase O in the second round exclusively at isocitrate dehydrogenase O in the second round exclusively at a-ketoglutarate dehydrogenase O in the second round at either isocitrate dehydrogenase or arketoglutarate dehydrogenase O In the third round exclusively at isocitrate dehydrogenase O In the third round exclusively at aketoglutarate dehydrogenase Oit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or a ketoglutarate dehydrogenase

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If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon be
lost as CO2? Ethanol is converted into acetyl COA by oxidation of the alcohol, first to
acetaldehyde, then to acetate followed by activation to form acetyl CoA.
For the following answers, the first round refers to the round of the CAC immediately upon entry
by the acetyl CoA.
O In the first round exclusively at isocitrate dehydrogenase
in the first round exclusively at a-ketoglutarate dehydrogenase
in the second round exclusively at isocitrate dehydrogenase
O in the second round exclusively at a-ketoglutarate dehydrogenase
O in the second round at either isocitrate dehydrogenase or aketoglutarate dehydrogenase
O in the third round exclusively at isocitrate dehydrogenase
O in the third round exclusively at a-ketoglutarate dehydrogenase
Oit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or a
ketoglutarate dehydrogenase
Transcribed Image Text:If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon be lost as CO2? Ethanol is converted into acetyl COA by oxidation of the alcohol, first to acetaldehyde, then to acetate followed by activation to form acetyl CoA. For the following answers, the first round refers to the round of the CAC immediately upon entry by the acetyl CoA. O In the first round exclusively at isocitrate dehydrogenase in the first round exclusively at a-ketoglutarate dehydrogenase in the second round exclusively at isocitrate dehydrogenase O in the second round exclusively at a-ketoglutarate dehydrogenase O in the second round at either isocitrate dehydrogenase or aketoglutarate dehydrogenase O in the third round exclusively at isocitrate dehydrogenase O in the third round exclusively at a-ketoglutarate dehydrogenase Oit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or a ketoglutarate dehydrogenase
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