If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon be lost as CO,? Ethanol is converted into acetyl CoA by oxidation of the alcohol, first to acetaldehyde, then to acetate followed by activation to form acetyl CoA. For the following answers, the first round refers to the round of the CAC immediately upon entry by the acetyl CoA. O In the first round exclusively at isocitrate dehydrogenase O in the first round exclusively at a-ketoglutarate dehydrogenase O in the second round exclusively at isocitrate dehydrogenase O in the second round exclusively at a-ketoglutarate dehydrogenase O in the second round at either isocitrate dehydrogenase or arketoglutarate dehydrogenase O In the third round exclusively at isocitrate dehydrogenase O In the third round exclusively at aketoglutarate dehydrogenase Oit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or a ketoglutarate dehydrogenase
If one were to ingest ethanol labeled with 1C at the methyl carbon, where would that carbon be lost as CO,? Ethanol is converted into acetyl CoA by oxidation of the alcohol, first to acetaldehyde, then to acetate followed by activation to form acetyl CoA. For the following answers, the first round refers to the round of the CAC immediately upon entry by the acetyl CoA. O In the first round exclusively at isocitrate dehydrogenase O in the first round exclusively at a-ketoglutarate dehydrogenase O in the second round exclusively at isocitrate dehydrogenase O in the second round exclusively at a-ketoglutarate dehydrogenase O in the second round at either isocitrate dehydrogenase or arketoglutarate dehydrogenase O In the third round exclusively at isocitrate dehydrogenase O In the third round exclusively at aketoglutarate dehydrogenase Oit will not be lost until at least the third round with loss possible at either isocitrate dehydrogenase or a ketoglutarate dehydrogenase
Chapter29: The Organic Chemistry Of Metabolic Pathways
Section29.SE: Something Extra
Problem 52AP
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Organic Chemistry of Metabolic Pathways
Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.
Glucogenesis
Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general definition for glucogenesis or gluconeogenesis is as follows,
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