Identify all resonance forms of the enolate formed, and indicate whether or not a substantial amount of starting ketone will be present together with the enolate at equilibrium. (select all that apply) °° No, there will NOT be a substantial amount of diketone present after equilibrium has been established. Yes, there will be a substantial amount of diketone present after equilibrium has been established.

On a scrap piece of paper, draw the curved arrow mechanism for the following reaction. Once you have determined the major product, draw it in the space below. 1) Ph MgCl, Et₂O 2) NH,C, H,O

18.04a5 Add curved arrow(s) to draw the final step of the mechanism. H₂O *-* CH3 H3C H3C H₂C H N CH3 Edit Drawing H₂C NO₂ CH3 CH3

Complete the following stepwise reaction mechanism problems based on the reaction conditions given:  Draw the stepwise mechanism.

Minoxidil is a molecule that causes hair growth in some people. It was originally synthesized as a vasodilator for the treatment of hypertension (high blood pressure). Most of the patients taking the drug for hypertension were seen to grow body hair. Due to other side effects, its oral use was stopped, but it became popular as a topical cream to promote hair growth. NH2 N-OH NH Minoxidil The first key reaction in one synthesis of minoxidil follows. Draw the product of this reaction. NH NC.

Draw the mechanism for the following reaction. 0 EtOH, HCI

5) A chemist is tasked with converting tetrahydro-2H-pyran-4-ol into 4-bromotetrahydro-2H-pyran. The chemist proposed two synthetic pathways to the desired product. Choose the pathway that produces the desired product, circle one and briefly explain your choice. A complete answer will explain how the chosen pathway produces the 4-bromotetrahydro-2H-pyran AND why the other pathway was not chosen. this nathway Synthetic Pathway #1 HBr OH Synthetic Pathway #2 1) TsCl, pyridine 2) NaBr

What is the reaction condition that could be employed to switch the major process between substitution and elimination mechanisms? O Concentration of the nucleophile/base O Proticity of the solvent O Polarity of the solvent Concentration of the substrate O Temperature

Draw the transition state for each reaction.

Identify the stronger nucleophile in the following pair of anions. HO− or Cl− in a polar aprotic solvent