I-cell disease is a classic example of an inherited human defect in protein targeting that affects an entire class of proteins: the soluble enzymes of the lysosome. What is the molecular defect in I-cell disease? Why does it affect the tar- geting of an entire class of proteins? What other types of mutations might produce the same phenotype?
Q: 26. Comparing and tiple allelic with polygenic inheritance. 27. Concept Mapping Complete the concept...
A: A concept map is a diagrammatic representation of interconnections between concepts and ideas. Most ...
Q: In rock pocket mice of the American Southwest, different extreme traits in mice of the same species ...
A: selection is a process in which certain natural traits are selected in an population that enhance th...
Q: Explain the conditions which creates problems in oxygen transport.
A: Introduction In this question we will discuss about the conditions which creates problems in transpo...
Q: 1. BUILD YOUR OWN CLADOGRAM. DIRECTIONS: Given the following organisms, create a simple cladogram an...
A: Cladogram is use to construct to show the difference and similarities between different organisms du...
Q: Joshua needs 150mL of 1X TBE buffer. The stock of TBE Buffer is 15X. How much 15X TBE buffer should ...
A: Cells constitute all the living organisms. These cells are the building blocks of life. Cells also c...
Q: RabA3 mi51 RabD2.a GA1 RabA5.b RabA5.e RabA2.b ZabA1.a RabE1.e rga RabC2.b RabD1 RabE1.d RNS1 MNSOD ...
A: Rab GTPase comes under the the ras superfamily of regulatory GTPase which mainly regulates the membr...
Q: List FOUR examples of angiosperm and/or gymnosperm plant species that are economically important
A: Angiosperms are plants with seeds enclosed in fruit whereas gymnosperms have naked seeds.
Q: How to synthesize mRNA ?
A: All cells employ replication, transcription, and translation to maintain track of their genetic mate...
Q: A virus in which life cycle can be triggered to enter into the other one? What triggers that event?
A: All infections rely upon cells for proliferation and metabolic cycles. Without help from anyone else...
Q: What are endoribonucleases ?
A: Introduction: endoribonucleases work primarily in RNA processing and turnover.
Q: polymerase EXCEPT: / Almal geld vir DNA-polimerase, BEHALWE: A. generates dsDNA from SSDNA / generee...
A: DNA polymerase enzymes are important during replication. Their function is to add nucleotides to th...
Q: What is common to both photosystems I and II? O Both involve the generation of oxygen Both involve t...
A: Photosynthesis is the process by which chlorophyll containing organisms produce simple organic molec...
Q: Can We Map Our Population’s Environmental Impact?
A: Humans have 95% modified each surface and are able to create maps that can track the categories of l...
Q: Explain the respiratory system
A: Answer :- The respiratory system is a natural framework comprising of explicit organs and constructi...
Q: 5. A eukaryotic cell can use glucose (C&H12O6) and hexanoic acid (C&H1402) as fuels for cellular res...
A: Cellular respiration is a process where organism produces energy for their own surviability.
Q: In your own words, define the terms “orthologous” and “paralogous” genes. Then briefly suggest by wh...
A: Often in the course of evolution, various strategies are followed for the expression of certain trai...
Q: Genetics Problem Set Answer each question carefully and identify any references used in APA format. ...
A: As per our guidelines we are supposed to answer only ? One question ( if there are multiple question...
Q: Why are LDLs (low-density lipoproteins) considered “losers” a) They are found in every fatty food b)...
A: Cholesterol is fatlike substance found in every body.
Q: How is Myrica faya comparative in territory inclination to numerous other N fixers? For what reason ...
A: These microbes are commonly called biological nitrogen fixers. Bacteria such as rhizobium and certai...
Q: you want to live forever and decide to make your cells telomerase active all the time. Expalin what ...
A: Ageing is the degenerative process that is associated with progressive accumulation of deleterious c...
Q: The photomicrograph below shows mitotically dividing cells from whitefish (Coregonus lavaretus). Wha...
A: If diploid of this species has 40 pair of chromosomes. At anaphase cell has 40 pair of centromere. A...
Q: Feature the different animals in the Philippines and how they are evolutionary related with one anot...
A: Philippines is a area where most of the evolutionary changes has taken place since a great time. The...
Q: How would you investigate the role of aquaporins in the uptake of water in these cells?
A: The limit of roots to take up not entirely set in stone to some degree by the obstruction of living ...
Q: Polypeptides, DNA and RNA are important in the process of Prokaryote cells and in the evolution of l...
A: DNA, RNA, and proteins are all long polymeric biomolecules in which all the monomers are attached si...
Q: I need help with Carbohydrate fermentation! Please indicate if each organism ferments the carbohydra...
A: Escherichia coli can ferment glucose and will produce acid. The phenol red will turn into yellow. Th...
Q: Can you tell me the statistics for survival and prognosis for malaria?
A: INTRODUCTION Malaria is a disease that mainly caused bya Parasite. There are four types of ...
Q: Mutations that affect organisms are those that involve exons. True or False. Defend your answer and ...
A: Introduction : A complete gene consists of Exon and intron . Esona are sequence of DNA or RNA t...
Q: 1. What two types of cells contain chloroplasts? 2. Autotrophs make their own food using energy from...
A: Answers
Q: Are alleles mixing between the populations? Is there evidence from DNA that alleles (variations of t...
A: In general the different alelles undergo mixing they form new recombinations with other allele, this...
Q: what is amgen and what is their purpose?
A: Amgen Inc. is a biotechnology firm that develops, manufactures, and markets human pharmaceuticals. A...
Q: BFR Is an example of "gym science" that has no merit as a training tool was devised at Ball State Ex...
A: BFR stands for blood flow restriction It decreases the blood outflow in veins ( total cut off ) And...
Q: Elaborate on the significance of mitotic and meiotic divisions in the transmission of traits
A: Mitosis It is the division of chromosomes in a cell. Usually followed by cytokinesis or cell divisi...
Q: Osmotic water permeability (10 cm/sec) Condition TIP MRNA injected Unrelated MRNA injected 1.25 0.15...
A: mRNA is synthesized in the nucleus using the nucleotide sequence of DNA as a template. This process ...
Q: : We know that the Pleistocene Epoch consists of periodic warming and cooling partially because of c...
A: True
Q: Give a brief description of the jaw patterns of the following: a.Chondricthyes b. Paleonisciform act...
A: Jaw pattern in fishes: Most bony fishes have two sets of jaws made mainly of bone. The primary oral...
Q: What is the importance of the first stage of the Calvin cycle? O To generate reducing power for anab...
A: Carbohydrates are required for supporting infinite life forms on Earth, and carbon dioxide is a cruc...
Q: v slow can the blood move before you can't detect
A: Answer :: given data, source is blood which is moving and the transducer is the stationary observ...
Q: Explain Bronchoconstriction in detail Link it to the respiratory system
A: Answer :- Bronchoconstriction is a condition where the smooth muscles of the bronchus contracts. The...
Q: GW501516 is a drug that activates PCG1alpha in cells to mimic the effects of endurance training True...
A: ANSWER;- True Explain;- To completely encounter the activity helping capacities, you want to know wh...
Q: Which of the following correctly describes a structural feature of DNA or RNA? a. RNA may fold into ...
A: The DNA and RNA both are nucleic acids that are made up of nucleotides. Nucleotides are made up of a...
Q: Type I fibers are only recruited in light repetitive movements like postural adjustment and slow wal...
A: The muscle fibres have a specialised structure that helps in contraction. Usually the actin and myos...
Q: Explain in detail antigen presentation pathway of the MHC molecule indicated
A: Antigen presentation is the interaction of antigen molecules on the surface of a macrophage or other...
Q: As exercise of a set intensity occurs over several hours The ratio of fat to carb calories used stay...
A: * Exercise intensity means the amount of energy required for physical activity per unit of time. *T...
Q: 12. Molecules can be transported across cell membranes in several ways. Compare and contrast the mol...
A: ****Note: since you have posted multiple questions so we will solve the first question for you. We ...
Q: Why is the Hardy Weinberg law of equilibrium important to a study of evolutionary processes? a. it...
A: There are some important points about Hardy Weinberg law : It is a rule that relates allelic and ge...
Q: Why is ropiness usually observed at the center of the bread? What is the selective agent used in t...
A:
Q: most STR fragments used in human forensic analysis are comprised of_____ repeats
A: STR Stands for short tandem repeats, these are short sequences in DNA that make large subunits (~100...
Q: QUESTION 25 When bound to its ligand, this type of receptor changes conformation to allow ions to mo...
A: Answer 25th answer is ion channel linked receptor
Q: What is the difference between Vo and Vmax? Why do enzyme-catalyzed reactions show substrate saturat...
A: Enzymes are biocatalyst that perform specific chemical reaction within our body. It is proteinaceous...
I-cell disease is a classic example of an inherited human defect in protein targeting that affects an entire class of proteins: the soluble enzymes of the lysosome. What is the molecular defect in I-cell disease? Why does it affect the tar- geting of an entire class of proteins? What other types of mutations might produce the same
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- The codon change (Gly-12 to Val-12) in human rasH that convertsit to oncogenic rasH has been associated with many types ofcancers. For this reason, researchers would like to develop drugs toinhibit oncogenic rasH. Based on your understanding of the Rasprotein, what types of drugs might you develop? In other words,what would be the structure of the drugs, and how would theyinhibit Ras protein? How would you test the efficacy of the drugs?What might be some side effects?Drug X shown below is a kinase inhibitor used to treat multiple types of breast cancer. Breast cancer cells are treated with the drug and after 8 hr are lysed and the presence of various proteins is shown by a band on a western blot. The presence of the phosphorylated form of the protein is shown by the presence of a band when probed with antibodies that recognize the phosphorylated form of protein and are indicated by a p- in front of protein name (e.g. p-AKT). Based on this information, which kinase is likely the target and is inhibited by Justify your answer in 3-4 sentences. Drug X. F FF N. -N S IZ H₂N `N No Drug (+) Drug p-AKT AKT p-GSK3B GSK3B p-p70S6K p70S6KMutations in the IL2RG gene cause approximately 30 percent of severe combined immunodeficiency disorder (SCID) cases in humans. These mutations result in alterations to a protein component of cytokine receptors that are essential for proper development of the immune system. The IL2RG gene is composed of eight exons and contains upstream and downstream sequences that are necessary for proper transcription and translation. Below are some of the mutations observed. For each, explain its likely influence on the IL2RG gene product (assume its length to be 375 amino acids). (a) Nonsense mutation in a coding region (b) Insertion in Exon 1, causing frameshift (c) Insertion in Exon 7, causing frameshift (d) Missense mutation (e) Deletion in Exon 2, causing frameshift (f) Deletion in Exon 2, in frame (g) Large deletion covering Exons 2 and 3
- Consider the following simple regulatory pathways. Assume the full pathway is shown. A- E- B- F- C- G- D- 1 A H- 2 B || L You identify several null mutations (a complete deletion of the gene). For each mutant (indicated with a - sign), determine whether the final product (I, J, K or L) is inducible, uninducible, or constitutive. 3 C 4 D- [Choose ] [Choose ] [Choose ] [Choose ] [Choose ] [Choose ] [Choose ] E [Choose ] F G I H || J KRNAi is currently being tested as a therapeutic tool for genetic diseases and other conditions. Consider the following: cystic fibrosis caused by loss of function of the CFTR gene, HIV infection, and cancer caused by hyperactivity of a growth factor receptor. Which of these may be treatable by RNAi, and which not? Explain your reasoning.The following is a portion of a protein: met-trp-tyr-arg-gly-pro-thr-Various mutant forms of this protein have been recovered. Using the normal and mutant sequences, determine the DNA and mRNA sequences that code for this portion of the protein, and explain each of the mutations. a. met-trp- b. met-cys-ile-val-val-leu-gln- c. met-trp-tyr-arg-ser-pro-thr- d. met-trp-tyr-arg-gly-ala-val-ile-ser-pro-thr-
- Cancer can be defined as an abnormal proliferation of cells that defy the normal regulatory controls observed by normal cells. Recently, histone deacetylation therapies have been attempted in the treatment of certain cancers [reviewed by Delcuve et al. (2009)]. Specifically, the FDA has approved histone deacetylation (HDAC) inhibitors for the treatment of cutaneous T-cell lymphoma. Explain why histone acetylation might be associated with cancer and what the rationale is for the use of HDAC inhibitors in the treatment of certain forms of cancer.You plan to synthesize a peptide to be used as a vaccine to treat melanoma, a particularly aggressive form of skin cancer. Normally, gp100, a protein on the surface of melanocytes, activates cell growth when it is bound by its ligand. Activation of the growth pathway depends on the presence of threonine in the ligand. The effective peptide vaccine will mimic the natural ligand, but won’t cause cell growth and division. Below is the sequence of the natural ligand: LDMKTAG In order to ensure your newly designed peptide vaccine does not cause cell growth upon binding, you must substitute the Threonine residue at position 5. What amino acid would you replace it with, bearing in mind that the peptide should still be similar enough to bind to the gp100 protein in the surface of melanocytes. Explain your choice. Your vaccine will be administered as a topical cream, and you require your peptide to have an overall neutral charge in order to be functional. At what pH should you formulate…A number of mutations affect the expression of the lac operon in E. coli. The genotypes of several E. coli strains are shown below. ("+" indicates a wild-type gene with normal function and "-" indicates a loss-of-function allele.) Please predict which of the following strains would have the lowest beta-galactosidase enzyme activity, when grown in the lactose medium. Orpt o* z* r* Orpt ot z* Y OrptoztY Orrotzr OrPotz*Y
- Consider the now dominant variant of the SARS-CoV-2 called the D614G mutation: a) The mutation changes an Aspartate (D, Asp) to a Glycine (G, Gly) at nucleotide position 614 (that’s why it’s called the D614G mutant) in the S1 subunit of the Spike protein. Using only the information above and a codon table, what are the mRNA codon sequences of the 2019-dominant and 2020-dominant Spike proteins? Note the figure above is not needed toanswer the question. Report in 5’ to 3' orientation __________________________________________ b) What type of substitution is this? In your answer, address the following: • The expected substitution in base sequence (e.g., A à C)• If the mutation is synonymous, nonsynonymous, or a frameshift• If the mutation is a transition or a transversion c) The mutation increases infectivity by reducing the stability of the Spike protein such that it can remain in the open conformation more often. The open conformation increases the chances of binding to the host ACE2…An individual carries a somatic mutation that changes a lysinecodon into a glutamic acid codon. Prior to acquiring this mutation,the individual had been exposed to UV light, proflavin, and5-bromouracil. Which of these three agents would be the mostlikely to have caused this somatic mutation? Explain your answer.Consider the following simple regulatory pathways. Assume the full pathway is shown. A- E- B- F- C- G- D- 1 H- A You identify several null mutations (a complete deletion of the gene). For each mutant (ind with a - sign), determine whether the final product (I, J, K or L) is inducible, uninducible, or constitutive. 2 B 3 C 4 D inducible inducible constitutive uninducible constitutive inducible inducible E uninducible F G H > > >