How is it possible Jonathan has the dominant disorder, Huntington’s Disease, if none of his family had it?   a) The mutant allele remained ‘hidden’ in previous generations. b) He is homozygous for mutant huntingtin alleles unlike his grandparents, who are clearly heterozygous for the condition. c) The appearance of Huntington Disease in him might be the result of a new mutation appearing during his lifetime. d) His parents and grandparents were ashamed to admit they had it.

The gene known to be mutated in cases of Agammaglobulinemia 2 (which is inherited in an autosomal recessive pattern) is the immunoglobulin lambda like polypeptide 1 (IGLL1 ENSG00000128322). What is known about the gene is recorded here: http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128322;r=22:23573125-23580302 Please navigate to the link above and click, 'show transcript table', to answer the following question: What is the size in amino acid residues of the IGLL1 transcript named IGLL1-203? NOTE: Please give your answer as a number, not a word, and do not type the units.

A man and a woman have a child with cystic fibrosis. Neither parent has cystic fibrosis. How could this happen? a) Both parents carry the cystic fibrosis allele, and each passed that allele to their child. b) The child had a spontaneous mutation on both copies of their CFTR alleles, leading to cystic fibrosis. c) One parent gave the child two copies of the cystic fibrosis CFTR allele. c) One parent gave the child a wild type CFTR allele, and the other parent gave them a cystic fibrosis CFTR gene.

Circle any inheritance patterns that could explain this pedigree. Assume individuals marrying into the family do not have a mutant allele. Please refer to the image attached. A) Paternally imprinted B) Maternally imprinted C) Maternal inheritance D) Autosomal recessive E) Autosomal dominant F) X-linked recessive G) X-linked dominant

12. The spindle checkpoint ensures that all chromosomes are attached to the mitotic spindle. If this does not happen, cells would most likely be arrested in A) telophase B) anaphase C) G2 D) metaphase 13. In the cells of some organisms, mitosis occurs without cytokinesis. This will result in A) cells with more than one nucleus. B) cells that are unusually small. C) cells lacking nuclei. D) cell cycles lacking an S phase. 14. Which of the following statements is true of a species that has a chromosome number of 2n = 16? A) The species is diploid with 32 chromosomes per cell. B) The species has 16 sets of chromosomes per cell. C) Each diploid cell has eight homologous pairs of chromosomes. D) A gamete from this species has four chromosomes.

If a gene is paternally imprinted, it means that: A.) it is on the X chromosome B.) it is on the Y chromosome C.) the allele inherited from the father is silenced D.) the allele inherited from the mother is silenced

A man with hemophilia, an X-linked recessive genetic disease, marries a woman who is a carrier for the same disease. What is the chance that one of their daughters will have hemophilia?  A) 0% B) 25% C) 50% D) 75% E) 100%

*Cystic fibrosis is a rare autosomal recessive condition. phenotypically normal man whose father had cystic fibrosis marries a phenotypically normal woman from outside the family.² a) Draw the pedigree as far as described. b) If the frequency of heterozygotes in the general population is 1/50, what is the probability that the couple's first child will have cystic fibrosis? c) If the first child does have cystic fibrosis, what is the probability that the second child will be normal?

Recessive genetic disorders are more frequent than disorders inherited as dominant because : a) recessive genetic disorders are limited to persons of the same ethnicity c) dominant genetic disorders are never expressed in males d) people carrying dominant genetic disorders always die before birth e ) carriers are not eliminated by the disease before reproduction

A reciprocal translocation occurs in an individual between chromosomes 4 and 18, and this translocation causes a disease in the individual. What is the most likely reason chromosome mutation causes a disease? a) The translocation causes a break in the chromosome in a gene regulatory region. b) Chromosomes with a translocation cannot replicate. c) An individual with a translocation has some genes duplicated. d) An individual with a translocation has some genes missing.