How does the movement of three positive Na ions out of the cell and two positive K ions into the cell make the inside of the cell negative?
Sodium postassium adenosine triphosphatase or sodium postassium pump is an enzyme which is found in membrane of cells and have many roles in physiology of cell.Sodium postassium pump was invented by Jens Christian Skou in 1957 who was a Danish Scientist.
Resting potential of a membrane is a static membrane potential of a cell.For maintainence of membrane potential of cell,there is low concentration of sodium ions and high level of postassium ions within the cells.
Sodium postassium pump causes the movement of three sodium ion outwards and 2 potassium ions inward and hence removal of total one positive charge ions from the cell.
So there are more cations expulsion from the cell than entry,so inside of cell remains negatively charged as compared to extracellular fluid.
Cell loses a positive charge in every cycle of sodium potassium pump because there is movement of three Sodium ions outward and two postassium ions inwards.
Hence there is maintainence of gradient of a higher concentration of sodium outside of cell and high level of postassium inside of cell.
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