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How does changing the position of -OH on a molecule affect the Phi Fand deactivation mechanism?.
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- BCX4430 is active against the Ebola virus. What class of drugs would BCX4430 belong to and suggest a mechanism of action of this drug. H2N HN- N. НО НО OH3. Atazanavir (structure below) is an orally delivered AIDS-drug which works as an inhibitor for the HIV aspartyl protease. OH Meo. .N. N. OMe `Ph Atazanavir i) Draw the high energy intermediate of an aspartyl protease-catalysed cleavage of the amide bond in the peptide R1-CO-NH-R?. ii) How well does Atazanavir follow the Lipinski's rules of five (log P 4.5)? IZ IZExplain triplet sensitizer
- H3CH₂C-MgBr a) D₂O + ? b) CD3OH c) CH3OD CH3CH₂D d) CD3ODWhich of the following substituent is an ortho/para-directing deactivator? a amino group b halogen group c phenyl group d carboxyl group22. Establishes which of the following chemical species is stabilized by inductive effect and by hyperconjugation.a) CH3+b) CH3-CH2+c) (CH3)C+
- provide brief explanation thnksD-glucose can form two isomers of glucosides after reaction with methanol in presence of catalytic HCI as shown below. Suggest a mechanism for the following reaction. CH2OH CH,OH CH2OH HO CH;OH но HO но но. но OCH3 HČI HO. OH ÓCH3 OH онExplain the mechanism for acid-catalyzed transesterification.