Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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identify by circling and numbering, 5 different functional groups in the molecule, provide the names of the functional groups

### Atorvastatin (Lipitor)

**Chemical Structure Overview:**

The image depicts the chemical structure of Atorvastatin, commonly known by the brand name Lipitor. This is a complex organic compound that features multiple functional groups and rings, characteristic of many pharmaceutical agents used in the management of cholesterol levels.

**Key Structural Features:**

1. **Hydroxyl Groups (OH):** Present at the top left of the structure, hydroxyl groups are indicative of alcohols and influence the solubility and reactivity of the compound.

2. **Carbonyl Group (C=O):** This group appears within the main chain and influences the compound's polarity and interaction with biological systems.

3. **Fluorophenyl Ring (F):** Located on the left side, the presence of a fluorine atom attached to a benzene ring impacts the molecule's lipophilicity and resistance to metabolic breakdown.

4. **Tert-butyl Group (C(CH3)3):** A bulky group that can affect the compound’s bioavailability and interaction with receptor binding sites.

5. **Pyrrole Ring (N):** A nitrogen-containing five-membered ring that contributes to the structural complexity and potential for specific biochemical interactions.

**Biological and Pharmacological Context:**

Atorvastatin is a widely used statin medication that helps lower cholesterol levels in the blood, thereby reducing the risk of cardiovascular diseases. It functions by inhibiting the enzyme HMG-CoA reductase, key in the mevalonate pathway of cholesterol synthesis in the liver.

Understanding the chemical structure of Atorvastatin is crucial for insights into its pharmacokinetics and pharmacodynamics, guiding its clinical use and development of similar therapeutic agents.
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Transcribed Image Text:### Atorvastatin (Lipitor) **Chemical Structure Overview:** The image depicts the chemical structure of Atorvastatin, commonly known by the brand name Lipitor. This is a complex organic compound that features multiple functional groups and rings, characteristic of many pharmaceutical agents used in the management of cholesterol levels. **Key Structural Features:** 1. **Hydroxyl Groups (OH):** Present at the top left of the structure, hydroxyl groups are indicative of alcohols and influence the solubility and reactivity of the compound. 2. **Carbonyl Group (C=O):** This group appears within the main chain and influences the compound's polarity and interaction with biological systems. 3. **Fluorophenyl Ring (F):** Located on the left side, the presence of a fluorine atom attached to a benzene ring impacts the molecule's lipophilicity and resistance to metabolic breakdown. 4. **Tert-butyl Group (C(CH3)3):** A bulky group that can affect the compound’s bioavailability and interaction with receptor binding sites. 5. **Pyrrole Ring (N):** A nitrogen-containing five-membered ring that contributes to the structural complexity and potential for specific biochemical interactions. **Biological and Pharmacological Context:** Atorvastatin is a widely used statin medication that helps lower cholesterol levels in the blood, thereby reducing the risk of cardiovascular diseases. It functions by inhibiting the enzyme HMG-CoA reductase, key in the mevalonate pathway of cholesterol synthesis in the liver. Understanding the chemical structure of Atorvastatin is crucial for insights into its pharmacokinetics and pharmacodynamics, guiding its clinical use and development of similar therapeutic agents.
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