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Give typed full explanation
Why do we assume that drug concentrations in venous and arterial blood are the same in pharmacokinetics?
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- Discuss the structures any synthetic drug should initially pass through before acting on the central nervous system Elaborate the physiological processes involved and the necessity of these anatomical structures.Present the comparison of pharmacokinetics vs pharmacodynamics. Why the identification of different types of receptors is so important for drug’s pharmacodymics?Give typing answer to all parts with explanation and conclusion (i) what the Biopharmacutics Classification System (BCS) is and why it is useful to classify drugs in this way, (ii) what the four classes in the system are and what they mean and (iii) what drug delivery challenges are present for each class of drug in terms of bioavailability.
- One of the initial symptoms a person can have for COVID-19 is the lost of taste and smell. Give a potential mechanism, including which portion of the reflex arc is being impacted, of how COVID is able to have this impact. Use an online source to support your argument.Explain in no more than 300 words how the principles of Pharmacokinetics workProvide a diagram of the EPH RECEPTOR B2 (EPHB2) structure. Give bioinformatics structure
- Synthetic opioids are frequently being used for analgesia, i.e. as pain killers. While morphine or other full agonists such as fentanyl are the strongest pain killers available, partial agonists such as nalorphine or pentazocine are being used in applications requiring something intermediate in strength between morphine and basic painkillers such as aspirin. Considering a situation where both morphine and pentazocine are co-administered, select the TRUE statement(s): A. With increasing concentrations of pentazocine, the percent maximal response for morphine can be reduced to the level of pentazocine. B. The dose-response curve for morphine will shift to the right and its shape will not change (parallel rightward shift). C. The dose-response curve for morphine will shift to the left and its shape will not change (parallel leftward shift). D. The maximal efficacy of morphine alone can be exceeded. E. None of the answers here is correct. Please answer asap and type your answer and…Which patch clamp technique should be used if you want to investigate the effect a compound has presynaptically with varying concentration?What is an example of two drugs that produce a synergistic (also known as hyperadditive) effect? What is the concern about drugs that have synergistic effects? Note: you can describe the classes of drugs rather than using specific drug names.
- What are some of the forces that control the strength of interaction between a drug and a receptor?Discuss three ways by which the human body is capable of utilising one single ligand in several ways by multiple cells? Give examples of each.Briefly describe the significance of drug clearance. How it affects the maintenance dose of the drug? List the major superfamilies of receptors that are involved in signal transduction. How it represents the targets of clinically used drugs? Give some examples
